PolysacDB Lipopolysaccharide 1078

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:03, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Escherichia coli O18:K1:H7

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 109

Antibody type and class

IgM

Assay System

ELISA, invitro opsonophagocytosis assay, immunoblotting, invivo protection studies

Cross-reactivity

This Mab cross-reacted with other 018 E. coli strains but were unreactive with heterologous 0 serotypes (e.g., 075 E. coli), E. coli J-5 Rc, Salmonella typhimurium Re rough mutants, or other gram-negative bacteria.

Proposed epitopes

The epitope was proposed to consist of the O-antigen

Proposed Utility

This Mab showed partial protection in invivo models

Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC261046 &tool=pmcentrez&rendertype=abstract PubMed Central]

External Links

• Link to PolysacDB database