CarboDB Capsular polysaccharide 2434
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Streptococcus suis serotype 2 reference strain S735
Basic Structure
N/A
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab Z3
Antibody type and class
IgG2b
Assay System
dot-ELISA, immunoblotting, electron microscopy, Opsonization and phagocytic assay, Protection assay, Bacterial clearance test
Cross-reactivity
This Mab reacted only with reference strains and field isolates of S. suis serotypes 1,2 and 1/2
Proposed epitopes
Mab Z3 reacts specifically with the sialic acid moiety of the capsule, a common constituent of the polysaccharidic capsular material of the three capsular types
Proposed Utility
This Mab was able to stabilize the capsule as shown by electron microscopy. Purified mAb Z3 was shown to significantly increase the rate of phagocytosis of S. suis cells by porcine monocytes and to activate the clearance of bacteria from the circulation in experimentally infected mice. mAb Z3 only offered partial protection to mice challenged with a minimal lethal dose
