CarboDB Lipopolysaccharide 2228
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Salmonella minnesota R 595 [Re]
Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Heat killed bacteria
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MASM2
Antibody type and class
IgG2b
Assay System
Enzyme immunoassay, ELISA
Cross-reactivity
This Mab cross-reacted with Salmoneela typhimurium SL1102 Re chemotype LPS
Proposed epitopes
3-deoxy-D-mannooctulosonic acid [KDO] residues at the terminal non-reducing ends seemed to be the part of the epitope. The particular epitope was proposed to be α-Kdo [2-->4] α-Kdo [2-->6] β-D-GlcN [1-->6] α-D-GlcN [1-PO3] tetrasaccharide
Proposed Utility
This Mab would help elucidate the Kdo LPS domain structure
