CarboDB Lipopolysaccharide 2208

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Salmonella enteritidis

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Tyvp-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Heat killed Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 177E6/A9

Antibody type and class

IgA

Assay System

ELISA and immunoblotting

Cross-reactivity

This Mab recognized O:9 antigen of subserogroup OD1 LPS as well as LPS from S. enteritidis as well as OD3 LPS antigen

Proposed epitopes

This Mab is directed to O:9 antigen of the LPS

Proposed Utility

This Mab agglutinated all Salmonella OD1 strains and OD3 strains and all S. enteritidis clinical isolates

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to CarboDB database