CarboDB Lipopolysaccharide 2170

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Salmonella typhimurium

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MO4-3

Antibody type and class

IgG3

Assay System

ELISA, immunoblotting

Cross-reactivity

This Mab was also specific but cross-reacted with Salmonella paratyphi serogroup A

Proposed epitopes

N/A

Proposed Utility

This Mab can be used as a serotyping reagent for the identification of serogroup B salmonellae in a routine diagnostic bacteriology laboratory

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to CarboDB database