CarboDB Core oligosaccharide 2036

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Core oligosaccharide

Carbohydrate Class

Core oligosaccharide [LPS]

Source Microbe

Pseudomonas aeruginosa

Basic Structure

The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Formalin killed whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab RM5

Antibody type and class

IgM

Assay System

ELISA

Cross-reactivity

"This Mab reacted specifically with P. aeruginosa Fisher immunotypes 2, 4, and 5"

Proposed epitopes

N/A

Proposed Utility

This Mab protected neutropenic mice prophylactically against challenge with P. aeruginosa immunotypes 2, 4, and 5,

Weblink

PubMed Central

External Links

• Link to CarboDB database