CarboDB Core oligosaccharide 2027
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Core oligosaccharide
Carbohydrate Class
Core oligosaccharide [LPS]
Source Microbe
Pseudomonas aeruginosa
Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
Proposed functions
N/A
Antigenic Nature used to produce antibodies
Heat killed Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 73.5
Antibody type and class
IgG1
Assay System
ELISA, flow cytometry, immunoblotting and immunogold electronmicroscopy
Cross-reactivity
The Mab cross-reacted with some of the other Pseudomonas spp such as P . Acidovorans, P.fluorescens, P. mendocina, P . pseudoalkaligenes, P. putida and P . Stutzeri and P. testosteroni but not with P. cepacia or Xanthomonas (Pseudomonas) maltophilia
Proposed epitopes
N/A
Proposed Utility
This Mab demonstrated opsonophagocytic killing of 06 subtype strains in the presence of human peripheral blood leukocytes and fresh human serum. This Mab also showed in vivo protection
