CarboDB Core oligosaccharide 2023
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Core oligosaccharide
Carbohydrate Class
Core oligosaccharide [LPS]
Source Microbe
Pseudomonas aeruginosa
Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
Proposed functions
N/A
Antigenic Nature used to produce antibodies
formalin-killed P. aeruginosa cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab OM-lD6
Antibody type and class
IgM
Assay System
ELISA, immunoblotting and flow cytometry
Cross-reactivity
This Mab bound to P. aeruginosa strains. OM-1D6 reacted with all strains of serotype G so far tested, and a few strains of serotype M
Proposed epitopes
This Mab reacted with the core region of the LPS. L-rhamnose in the LPS core of serotype G was an immunodominant sugar recognized by OM-1D6
Proposed Utility
This Mab showed a high level of protective activity against P.aeruginosa in an experimental infection model using normal mice
