CarboDB Capsular polysaccharide 1806

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Neisseria meningitidis group B

Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

Proposed functions

It is an important virulence factor

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 101C11

Antibody type and class

IgG2a

Assay System

ELISA and bactericidal assays

Cross-reactivity

This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab also recognized N-propionylated capsular polysaccharide of group B meningitidis

Proposed epitopes

α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope

Proposed Utility

This Mab had potent bactericidal activity

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to CarboDB database