CarboDB Phenolic glycolipid TB antigen 1743

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Phenolic glycolipid TB antigen

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium tuberculosis canetti

Basic Structure

Phenolic glycolipid consist of phenol phthiocerol as a common structure and a carbohydrate determinant that consists of 2,3,4-Me3Fuc-Rha-2-O-MeRha residues

Proposed functions

It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab III604

Antibody type and class

IgG3

Assay System

ELISA and dot ELISA

Cross-reactivity

This Mab was specific to M. tuberculosis phenolic glycolipid and did not cross-react with other phenolic glycolipids from Mycobacterium leprae, M. bovis, and M. kansasii

Proposed epitopes

N/A

Proposed Utility

This Mab may be useful as a diagnostic reagent

Weblink

PubMed Central

External Links

• Link to CarboDB database