CarboDB Lipooligosaccharide 1624
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Lipooligosaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Moraxella catarrhalis serotype A
Basic Structure
LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo
Proposed functions
Moracella lipooligosaccharide is a potential virulence factor
Antigenic Nature used to produce antibodies
heat inactivated Moraxella catarrhalis serotype A
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 219A9
Antibody type and class
IgM
Assay System
ELISA, bactericidal assays and immunofluorescence assay
Cross-reactivity
MAb 219A9 was specific for a common epitope of A, B, and C M. catarrhalis serotypes. It also cross-reacted with whole bacteria and LPS antigens isolated from non-typeable H. influenzae and H. parainfluenzae strains
Proposed epitopes
6-linked branch α-D-Galpara-(1-->4)-β-D-Galpara-(1-->4)-α-D-Glcpara-(1-->2)-β-D-lcpara seemed to be a part of the epitope
Proposed Utility
This Mab possessed a strong bactericidal effect against the three serotypes in the presence of complement
