CarboDB Lipophosphoglycan 1548

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipophosphoglycan

Carbohydrate Class

Miscellaneous

Source Microbe

Leishmania mexicana

Basic Structure

LPG contains [PO4-->6Gal(β1-->4)Man(α1)] phosphosaccharide repeats linked to a conserved phosphosaccharide core and a conserved lyso alkylphosphatidylinositol residue. In contrast to L. donovani LPG, which exclusively contains the phosphodisaccharide repeats

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Con A binding proteins

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab AP3

Antibody type and class

IgG1

Assay System

ELISA, immunoblotting

Cross-reactivity

This Mab cross-reacted with a highly glycosylated protein - acid phosphatase

Proposed epitopes

The epitope was proposed to consist of phosphosaccharide repeats or the sugar residues forming the cap at the non-reducing end

Proposed Utility

the epitopes recognized by this Mab have been localized in promastigotes and infected macrophages

Weblink

PubMed

External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to CarboDB database