CarboDB Capsular polysaccharide 1465

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Enterococcus faecalis 12030

Basic Structure

Glycerol teichoic acid-like molecules with a carbohydrate backbone structure of 6-α-D-glucose- 1-->2 glycerol-3-PO4 with substitution on carbon 2 of the glucose with an α-2-1-D-glucose residue

Proposed functions

These polysaccharides are major virulence factors

Antigenic Nature used to produce antibodies

Capsular polysaccharide

Carrier Name

nil

Conjugation Method

nil

Antibodies

Polysera

Antibody type and class

IgM

Assay System

ELISA and opsonophagocytic assay

Cross-reactivity

The antisera cross-reacted with Enterococcus faecalis OG1RF and against two serologically related, vancomycin-resistant Enterococcus faecium clinical isolates

Proposed epitopes

N/A

Proposed Utility

These antibodies may be useful for prophylaxis and treatment of enterococcal infections

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to CarboDB database