CarboDB Lipopolysaccharide 1457
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Haemophilus influenzae RM.7004
Basic Structure
It consists of an oligosaccharide linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to a lipid A region. The core is often divided into two regions: an inner core consisting of a heptose (Hep) and a Kdo residue and an outer core containing galactose (Gal) and glucose (Glc)
Proposed functions
LPS plays an important role in the infection process
Antigenic Nature used to produce antibodies
azide-killed H. influenzae RM.7004
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MAHI 3
Antibody type and class
IgG2b
Assay System
enzyme immunoassay, colony dot immunoblotting, and immunoblotting
Cross-reactivity
MAHI 3 bound to all H. influenzae, all other human Haemophilus spp., all Bordetella pertussis and Bordetella parapertussis, and all Aeromonas spp. tested but not to any Neisseria or Moraxella catarrhalis strains
Proposed epitopes
The structural element recognized by MAHI 3 is Hepα1-->2Hepα1-->3Hepα1-->Kdo together with part of lipid A, including the phosphate
Proposed Utility
This Mab would help to detect the organism in environmental samples and clinical specimens
