CarboDB Lipopolysaccharide 1183
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Bordetella pertusis 18530
Basic Structure
N/A
Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
Antigenic Nature used to produce antibodies
B. pertussis 18530 LPS
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 6-4-H6
Antibody type and class
IgG3
Assay System
ELISA
Cross-reactivity
This antibody cross-reacted with delipidated polysaccharide fragments (PS-1 and PS-2). did not react with LPS prepared from B. parapertussis and B. bronchiseptica. No cross-reactions were observed with strains of Branhamella catarrhalis, Neisseria meningitidis, Streptococcus miteor, Haemophilus influenza, or Legionella pneumophila
Proposed epitopes
N/A
Proposed Utility
This Mab might be useful for the detection of soluble antigens and whole bacteria in clinical samples and for studies of the immunochemical structure of B. pertussis LPS.
