CarboDB Glucurunoxylomannan 1013
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Glucurunoxylomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Cryptococcus neoformans serotype A
Basic Structure
The GXM backbone consists of a linear α(1-->3)-linked mannan substituted at 2-O positions by single residues of either xylose or glucuronic acid
Proposed functions
Antiphagocytic ; an important virulence factor
Antigenic Nature used to produce antibodies
Pure Capsular polysaccharide
Carrier Name
N/A
Conjugation Method
N/A
Antibodies
Mab E1
Antibody type and class
IgG1
Assay System
Agglutination with C. neoformans serotype A cells, Radial immunodiffusion, Indirect Immunofluorescence,, ELISA, Competitive binding assays
Cross-reactivity
This antibody was highly specific to serotype A, low levels of cross reactivity to serotypes B and D. Among the other yeasts tested, a cross-reaction was only detected with Trichosporon beigelii.
Proposed epitopes
N\A
Proposed Utility
could be useful for fundamental studies on the glucuronoxylomannan structure, as well as for clinical applications such as serotyping and possibly the serological diagnosis of cryptococcosis
