From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 18:52, 9 March 2010

Rv2121c
Name
ATP phosphoribosyltransferase (hisG)
Identifiers
Swiss Prot	P60759
Genbank	888689
PDB	1NH7
Chemical data
Formula	C12H9BrO5 [1]
Mol. wt.	30482 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	4.7128

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

General

THOUGHT TO BE INVOLVED IN HISTIDINE BIOSYNTHESIS.

Product: Probable ATP phosphoribosyltransferase HisG

Other PDBID: 1NH8 Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

Protein Sequence

>Rv2121c, TB.seq 2379807:2380658 MW:30482 MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSGELDFGITGRDLVCDSGAQVR ERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGR TLSQHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIA PLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF

Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q16836.2	23	50	69	4.1
sp|O14531.2	31	43	90	4.3

Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

Subcellular Location

Link to TBpred
Cytoplasmic

Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

B cell Epitopes

BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

IEDB Analysis

Link to IEDB
Result Predicited by [4]

MHC Class-I Binder

nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

IEDB Analysis

Link to IEDB
Result Predicted by [6]

MHC Class-II Binder

Propred Analysis

Link to Propred
Result Predicted by [7]

NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.