From DrugPedia: A Wikipedia for Drug discovery

Revision as of 11:02, 27 February 2010 (edit) Nitinkumar (Talk | contribs) (New page: {{immunebox | Name =<b> DNA polymerase III subunits gamma and tau </b> |image= | width=250 |image2= |Swiss Prot = P63975 | Genbank = 885361 | PDB = | Dru...) ← Previous diff		Current revision (11:46, 27 February 2010) (edit) (undo) Nitinkumar (Talk | contribs)
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	==NetMHC-II Analysis==		==NetMHC-II Analysis==
	Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br>		Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br>
-	Result Predicted by	+	Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv37216.txt]<br>
	=External Links=		=External Links=

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Current revision

Rv3721c
Name
DNA polymerase III subunits gamma and tau
Identifiers
Swiss Prot	P63975
Genbank	885361
PDB	?
Chemical data
Formula	C14H10BrNO3 [1]
Mol. wt.	61892 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	5.68

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

[edit] General

DNA POLYMERASE III IS A COMPLEX, MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3' TO 5' EXONUCLEASE ACTIVITY [CATALYTIC ACTIVITY: N DEOXYNUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + DNA(N)].

Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

[edit] Protein Sequence

>Rv3721c, TB.seq 4164995:4166728 MW:61892 VALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTANPCGVCESCVSLA PNAPGSIDVVELDAASHGGVDDTRELRDRAFYAPVQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEK VLPTIRSRTHHYPFRLLPPRTMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLSVLDQLLAGAADTHVTYTRALGL LGVTDVALIDDAVDALAACDAAALFGAIESVIDGGHDPRRFATDLLERFRDLIVLQSVPDAASRGVVDAPEDALDRMREQ AARIGRATLTRYAEVVQAGLGEMRGATAPRLLLEVVCARLLLPSASDAESALLQRVERIETRLDMSIPAPQAVPRPSAAA AEPKHQPAREPRPVLAPTPASSEPTVAAVRSMWPTVRDKVRLRSRTTEVMLAGATVRALEDNTLVLTHESAPLARRLSEQ RNADVLAEALKDALGVNWRVRCETGEPAAAASPVGGGANVATAKAVNPAPTANSTQRDEEEHMLAEAGRGDPSPRRDPEE VALELLQNELGARRIDNA

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|P35249.2	25	42	304	2e-14
sp|P40937.1	24	44	234	2e-11
sp|P35250.3	25	41	224	3e-09
sp|Q96S55.2	24	37	206	0.15
sp|Q8WXX0.1	28	44	98	0.82

[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Cytoplasmic

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.