Structural annotation of Rv2753c (dihydrodipicolinate synthase)
From DrugPedia: A Wikipedia for Drug discovery
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NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR | NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR | ||
| - | = | + | =Tertiary Structure= |
This protein structure is available in PDB and having code [http://www.rcsb.org/pdb/explore/explore.do?structureId=1XXX 1XXX] | This protein structure is available in PDB and having code [http://www.rcsb.org/pdb/explore/explore.do?structureId=1XXX 1XXX] | ||
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Discussion on this protein available at TopSCAN [http://www.topsan.org/Proteins/XMTB/1xxx 1XXX] | Discussion on this protein available at TopSCAN [http://www.topsan.org/Proteins/XMTB/1xxx 1XXX] | ||
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| + | ==Structure Prediction== | ||
| + | As information is available so we are not applying protein structure prediction method | ||
= Structure Classification = | = Structure Classification = | ||
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Structural classification of 1XXX as per CATH [http://www.cathdb.info/pdb/1xxx CATH_1XXX] | Structural classification of 1XXX as per CATH [http://www.cathdb.info/pdb/1xxx CATH_1XXX] | ||
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| - | + | ==Secondray Structure== | |
| + | Secondary structure of this protein (assigned using DSSP) [ftp://ftp.cmbi.kun.nl/pub/molbio/data/dssp/1xxx.dssp 1XXX.DSSP] | ||
| - | + | ==Secondary Structure Prediction== | |
| - | = | + | We are not applying structure prediction method as structure is available |
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| + | =Related Publications= | ||
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis. [http://www.ncbi.nlm.nih.gov/pubmed/18062777?dopt=Abstract Biochem J. 2008 Apr 15;411(2):351-60] | Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis. [http://www.ncbi.nlm.nih.gov/pubmed/18062777?dopt=Abstract Biochem J. 2008 Apr 15;411(2):351-60] | ||
Current revision
| Structural annotation of Rv2753c (dihydrodipicolinate synthase)
| |
| Name | |
| Dihydrodipicolinate Synthase | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | |
| Chemical data | |
| Formula | ? |
| Mol. wt. | 30,858 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 5.57 |
Contents |
[edit] General
dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.
This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.
[edit] Amino Acid Sequence of Rv2753c
>Rv2753c, TB.seq 3066222:3067121 MW:30827 VTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
[edit] Tertiary Structure
This protein structure is available in PDB and having code 1XXX
Detail information available at OCA browser 1XXX
Discussion on this protein available at TopSCAN 1XXX
[edit] Structure Prediction
As information is available so we are not applying protein structure prediction method
[edit] Structure Classification
Protein: Dihydrodipicolinate synthase from Mycobacterium tuberculosis SCOP_1XXX
Structural classification of 1XXX as per CATH CATH_1XXX
[edit] Secondray Structure
Secondary structure of this protein (assigned using DSSP) 1XXX.DSSP
[edit] Secondary Structure Prediction
We are not applying structure prediction method as structure is available
[edit] Related Publications
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis. Biochem J. 2008 Apr 15;411(2):351-60
Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase. Protein Sci. 2008 Dec;17(12):2080-90. Epub 2008 Sep 11
