Differences between Mtu strains
From DrugPedia: A Wikipedia for Drug discovery
(Difference between revisions)
| Line 43: | Line 43: | ||
|2:1 | |2:1 | ||
|{{UniProt2|A5U119|MRA_0985}}, {{UniProt2|A5U122|MRA_0987}} | |{{UniProt2|A5U119|MRA_0985}}, {{UniProt2|A5U122|MRA_0987}} | ||
| - | | [http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=EAX12868.1 | + | | [http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=EAX12868.1 TBFG_00986] |
| (Rv00980c, Rv00986c) PE-PGRS family proteins | | (Rv00980c, Rv00986c) PE-PGRS family proteins | ||
|- | |- | ||
| Line 50: | Line 50: | ||
| [http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=EAX15309.1 TBFG_03453] | | [http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=EAX15309.1 TBFG_03453] | ||
| (Rv1587c) REP13E12 repeat protein; (Rv3467) unchar. | | (Rv1587c) REP13E12 repeat protein; (Rv3467) unchar. | ||
| + | |- | ||
| + | |2:1 | ||
| + | |{{UniProt2|A5U5B9|MRA_2450}}, {{UniProt2|A5U4K4|MRA_2192}} | ||
| + | | {{UniProt2|A5WQ40|TBFG_02411}} | ||
| + | | (Rv2424c) (transposase IS116/IS110/IS902 family protein) | ||
| + | |- | ||
| + | |2:1 | ||
| + | | [http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=ABQ75300.1 MRA_3515], {{UniProt2|A5U601|MRA_2672}} | ||
| + | | {{UniProt2|A5WQ40|TBFG_02411}} | ||
| + | | (Rv3475) (transposase IS6110); (Rv1764) (transposase IS1558) | ||
| + | |- | ||
| + | |2:1 | ||
| + | |{{UniProt2|A5U618|MRA_2694}}, {{UniProt2|A5U192|MRA_3147}} | ||
| + | | {{UniProt2|A5WQR9|TBFG_02644}} | ||
| + | | Truncated IS1081 transposase; (Rv2512c) transposase IS1081 | ||
|- | |- | ||
|} | |} | ||
Revision as of 11:10, 7 January 2010
There are several ways to look at pairwise differences between Mtu strains:
- pairwise differences in the nucleotids of the genomes
- pairwise differences in the amino acid sequences
- pairwise proteomic differences (orthologs, missing genes, gene doubling, additions like prophages)
- pairwise functional differences where known
Since we now have complete genomes of several strains of Mtu, and we have pairs of orthologs for both from a highly accurate algorithm (OMA), and the highly correct phylogenetic trees from OMA show us which strains are nearest, we can most easily give orthologs and paralogs between nearest pairs of strains.
| name | H37Ra | F11 | (H37Rv) function |
|---|---|---|---|
| number of genes | 3990 | 3855 | |
| 1:1 orthologs | 3725 | see this file | |
| 1:n orthologs | 0 | ||
| n:1 orthologs | 12 | ||
| n:m orthologs | 40 | ||
| 2:1 | MRA_0985, MRA_0987 | TBFG_00986 | (Rv00980c, Rv00986c) PE-PGRS family proteins |
| 2:1 | MRA_1598, MRA_3507 | TBFG_03453 | (Rv1587c) REP13E12 repeat protein; (Rv3467) unchar. |
| 2:1 | MRA_2450, MRA_2192 | TBFG_02411 | (Rv2424c) (transposase IS116/IS110/IS902 family protein) |
| 2:1 | MRA_3515, MRA_2672 | TBFG_02411 | (Rv3475) (transposase IS6110); (Rv1764) (transposase IS1558) |
| 2:1 | MRA_2694, MRA_3147 | TBFG_02644 | Truncated IS1081 transposase; (Rv2512c) transposase IS1081 |
