Immunotation of Rv2753c (dihydrodipicolinate synthase)

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(→MHC Class-I Binder)
(→MHC Class-I Binder)
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Result Predicted by  
Result Predicted by  
[http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
[http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
-
<!--table border='1'><tr><td>
 
-
Epitope</td><td>No of Alleles
 
-
</td></tr><tr><td>
 
-
VPIEPDTIR </td><td>      15
 
-
</td></tr><tr><td>
 
-
TPFSGDGSL </td><td>      14
 
-
</td></tr><tr><td>
 
-
TLSKAGLRL </td><td>      13
 
-
</td></tr><tr><td>
 
-
IEPDTIRAL </td><td>      13
 
-
</td></tr><tr><td>
 
-
GTYDTAHSI </td><td>      13
 
-
</td></tr><tr><td>
 
-
DDALNLPWL </td><td>      11
 
-
</td></tr><tr><td>
 
-
GFISVIAHL  </td><td>    10
 
-
</td></tr><tr><td>
 
-
GATGFISVI </td><td>      10
 
-
</td></tr><tr><td>
 
-
ATPEQIDAL </td><td>      10
 
-
</td></tr><tr><td>
 
-
YDTAHSIRL </td><td>      9
 
-
</td></tr><tr><td>
 
-
GDIATARKI  </td><td>    9
 
-
</td></tr><tr><td>
 
-
AVLEAVGDR  </td><td>    9
 
-
</td></tr><tr><td>
 
-
ASHPNIVGV  </td><td>    9
 
-
</td></tr><tr><td>
 
-
QRGLQAHFT  </td><td>    7
 
-
</td></tr><tr><td>
 
-
GLQAHFTAV  </td><td>    7
 
-
</td></tr><tr><td>
 
-
AVGDRARVI  </td><td>    7
 
-
</td></tr><tr><td>
 
-
YSGDDALNL  </td><td>    6
 
-
</td></tr><tr><td>
 
-
VGFDVAARL  </td><td>    6
 
-
</td></tr><tr><td>
 
-
QLRELLSAF </td><td>      6
 
-
</td></tr><tr><td>
 
-
TAVADATEL </td><td>      5
 
-
</td></tr><tr><td>
 
-
TAARLANHL  </td><td>    5
 
-
</td></tr><tr><td>
 
-
LLRAVLEAV  </td><td>    5
 
-
</td></tr><tr><td>
 
-
GEKIELLRA  </td><td>    5
 
-
</td></tr><tr><td>
 
-
DTATAARLA  </td><td>    5
 
-
</td></tr><tr><td>
 
-
AAGQLRELL  </td><td>    5
 
-
</td></tr><tr><td>
 
-
TDGEKIELL  </td><td>    4
 
-
</td></tr><tr><td>
 
-
QAHFTAVAD  </td><td>    4
 
-
</td></tr><tr><td>
 
-
MSRLGGVTL  </td><td>    4
 
-
</td></tr><tr><td>
 
-
LDTATAARL  </td><td>    4
 
-
</td></tr><tr><td>
 
-
HPNIVGVKD  </td><td>    4
 
-
</td></tr><tr><td>
 
-
GVKDAKADL  </td><td>    4
 
-
</td></tr><tr><td>
 
-
DGEKIELLR  </td><td>    4
 
-
</td></tr><tr><td>
 
-
KIELLRAVL </td><td>      3
 
-
</td></tr><tr><td>
 
-
HSIRLAKAC  </td><td>    3
 
-
</td></tr><tr><td>
 
-
GSGDIATAR  </td><td>    3
 
-
</td></tr><tr><td>
 
-
AHLAAGQLR  </td><td>    3
 
-
</td></tr><tr><td>
 
-
PTTTDGEKI  </td><td>    2
 
-
</td></tr><tr><td>
 
-
IAHLAAGQL </td><td>      2
 
-
</td></tr><tr><td>
 
-
DLHSGAQIM  </td><td>    2
 
-
</td></tr><tr><td>
 
-
</table--!>
 
-
 
-
===MHC Class-II Binder===
 
-
Result predicted by [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHCII]
 
-
<table border='1'><tr><td>
 
-
Epitope</td><td>No of Alleles
 
-
</td></tr><tr><td>
 
-
TGFISVIAHLAAGQL</td><td> 6
 
-
</td></tr><tr><td>
 
-
GFISVIAHLAAGQLR</td><td> 6
 
-
</td></tr><tr><td>
 
-
PDTIRALASHPNIVG </td><td>4
 
-
</td></tr><tr><td>
 
-
GATGFISVIAHLAAG </td><td>4
 
-
</td></tr><tr><td>
 
-
ATGFISVIAHLAAGQ </td><td>4
 
-
</td></tr><tr><td>
 
-
TELPMLLYDIPGRSA </td><td>3
 
-
</td></tr><tr><td>
 
-
MGATGFISVIAHLAA</td><td> 3
 
-
</td></tr><tr><td>
 
-
LVVTPYYSKPPQRGL </td><td>3
 
-
</td></tr><tr><td>
 
-
GQLRELLSAFGSGDI</td><td> 3
 
-
</td></tr><tr><td>
 
-
FISVIAHLAAGQLRE</td><td> 3
 
-
</td></tr><tr><td>
 
-
DTIRALASHPNIVGV</td><td> 3
 
-
</td></tr><tr><td>
 
-
QLRELLSAFGSGDIA</td><td> 2
 
-
</td></tr><tr><td>
 
-
PEQIDALAADMRAAS</td><td> 2
 
-
</td></tr><tr><td>
 
-
NLPWLAMGATGFISV</td><td> 2
 
-
</td></tr><tr><td>
 
-
LPWLAMGATGFISVI</td><td> 2
 
-
</td></tr><tr><td>
 
-
LNLPWLAMGATGFIS</td><td> 2
 
-
</td></tr><tr><td>
 
-
LLVVTPYYSKPPQRG</td><td> 2
 
-
</td></tr><tr><td>
 
-
LGGVTLSKAGLRLQG</td><td> 2
 
-
</td></tr><tr><td>
 
-
KAGLRLQGIDVGDPR</td><td> 2
 
-
</td></tr><tr><td>
 
-
IAGAGTYDTAHSIRL</td><td> 2
 
-
</td></tr><tr><td>
 
-
GLLVVTPYYSKPPQR</td><td>2
 
-
</td></tr><tr><td>
 
-
GGVTLSKAGLRLQGI</td><td> 2
 
-
</td></tr><tr><td>
 
-
EPDTIRALASHPNIV</td><td> 2
 
-
</td></tr><tr><td>
 
-
ELPMLLYDIPGRSAV </td><td>2
 
-
</td></tr><tr><td>
 
-
ATELPMLLYDIPGRS </td><td>2
 
-
</td></tr><tr><td>
 
-
ALNLPWLAMGATGFI</td><td> 2
 
-
</td></tr><tr><td>
 
-
AGQLRELLSAFGSGD</td><td> 2
 
-
</td></tr><tr><td>
 
-
AGLRLQGIDVGDPRL</td><td> 2
 
-
</td></tr><table>
 
<br>  
<br>  
Result Predicited by [http://www.imtech.res.in/raghava/propred/ Propred]
Result Predicited by [http://www.imtech.res.in/raghava/propred/ Propred]
-
<table border='1'><tr><td>
 
-
Epitope</td><td> No of Alleles
 
-
</td></tr><tr><td>
 
-
IRLAKACAA  </td><td>    51
 
-
</td></tr><tr><td>
 
-
INIAVAPLC  </td><td>    51
 
-
</td></tr><tr><td>
 
-
VVSGTTGES  </td><td>    48
 
-
</td></tr><tr><td>
 
-
LLVVTPYYS </td><td>      48
 
-
</td></tr><tr><td>
 
-
IRALASHPN </td><td>      46
 
-
</td></tr><tr><td>
 
-
LTAMVTPFS  </td><td>    44
 
-
</td></tr><tr><td>
 
-
LQAHFTAVA  </td><td>    43
 
-
</td></tr><tr><td>
 
-
LGTLLTAMV  </td><td>    43
 
-
</td></tr><tr><td>
 
-
LLTAMVTPF  </td><td>    42
 
-
</td></tr><tr><td>
 
-
VAPLCNAMS  </td><td>    41
 
-
</td></tr><tr><td>
 
-
IATARKINI </td><td>      40
 
-
</td></tr><tr><td>
 
-
LRELLSAFG </td><td>      38
 
-
</td></tr><tr><td>
 
-
LLYDIPGRS  </td><td>    38
 
-
</td></tr><tr><td>
 
-
LVVSGTTGE  </td><td>    37
 
-
</td></tr><tr><td>
 
-
VIAHLAAGQ  </td><td>    36
 
-
</td></tr><tr><td>
 
-
MLLYDIPGR  </td><td>    36
 
-
</td></tr><tr><td>
 
-
LRLQGIDVG  </td><td>    35
 
-
</td></tr><tr><td>
 
-
ISVIAHLAA  </td><td>    34
 
-
</td></tr><tr><td>
 
-
LQGIDVGDP  </td><td>    33
 
-
</td></tr><tr><td>
 
-
FISVIAHLA </td><td>      33
 
-
</td></tr><tr><td>
 
-
WLAMGATGF  </td><td>    32
 
-
</td></tr><tr><td>
 
-
LLRAVLEAV  </td><td>    30
 
-
</td></tr><tr><td>
 
-
IELLRAVLE  </td><td>    30
 
-
</td></tr><tr><td>
 
-
YYSKPPQRG  </td><td>    25
 
-
</td></tr><tr><td>
 
-
IAVAPLCNA </td><td>      24
 
-
</td></tr><tr><td>
 
-
LAADMRAAS </td><td>      22
 
-
</td></tr><tr><td>
 
-
IVGVKDAKA </td><td>      22
 
-
</td></tr><tr><td>
 
-
LCNAMSRLG </td><td>      21
 
-
</td></tr><tr><td>
 
-
LANHLVDQG  </td><td>    21
 
-
</td></tr><tr><td>
 
-
LAMGATGFI  </td><td>    21
 
-
</td></tr><tr><td>
 
-
FGSGDIATA  </td><td>    20
 
-
</td></tr><tr><td>
 
-
YSGDDALNL </td><td>      19
 
-
</td></tr><tr><td>
 
-
VGFDVAARL </td><td>      18
 
-
</td></tr><tr><td>
 
-
LRAVLEAVG </td><td>      17
 
-
</td></tr><tr><td>
 
-
LGGVTLSKA </td><td>      17
 
-
</td></tr><tr><td>
 
-
IEPDTIRAL </td><td>      17
 
-
</td></tr><tr><td>
 
-
LVVTPYYSK </td><td>      16
 
-
</td></tr><tr><td>
 
-
LSKAGLRLQ  </td><td>    16
 
-
</td></tr><tr><td>
 
-
LHSGAQIMA </td><td>      16
 
-
</td></tr><tr><td>
 
-
IMADTGLAY </td><td>      16
 
-
</td></tr><tr><td>
 
-
IAHLAAGQL  </td><td>    16
 
-
</td></tr><tr><td>
 
-
VGVKDAKAD </td><td>      15
 
-
</td></tr><tr><td>
 
-
MVTPFSGDG  </td><td>    15
 
-
</td></tr><tr><td>
 
-
LASHPNIVG </td><td>      15
 
-
</td></tr><tr><td>
 
-
FSGDGSLDT  </td><td>    14
 
-
</td></tr><tr><td>
 
-
LNLPWLAMG </td><td>      13
 
-
</td></tr><tr><td>
 
-
VGDRARVIA </td><td>      12
 
-
</td></tr><tr><td>
 
-
IAGAGTYDT </td><td>      11
 
-
</td></tr><tr><td>
 
-
FDVAARLGT </td><td>      11
 
-
</td></tr><tr><td>
 
-
IPGRSAVPI </td><td>      10
 
-
</td></tr><tr><td>
 
-
VTPYYSKPP  </td><td>    9
 
-
</td></tr><tr><td>
 
-
MSRLGGVTL </td><td>      9
 
-
</td></tr><tr><td>
 
-
LSAFGSGDI  </td><td>    9
 
-
</td></tr><tr><td>
 
-
YDTAHSIRL </td><td>      8
 
-
</td></tr><tr><td>
 
-
VTLSKAGLR </td><td>      6
 
-
</td></tr><tr><td>
 
-
MGATGFISV  </td><td>    5
 
-
</td></tr><tr><td>
 
-
LYDIPGRSA  </td><td>    5
 
-
</td></tr><tr><td>
 
-
LVDQGCDGL </td><td>      5
 
-
</td></tr><tr><td>
 
-
LAYYSGDDA </td><td>      5
 
-
</td></tr><tr><td>
 
-
VAARLGTLL </td><td>      4
 
-
</td></tr><tr><td>
 
-
LDTATAARL </td><td>      4
 
-
</td></tr><tr><td>
 
-
VTPFSGDGS  </td><td>    3
 
-
</td></tr><tr><td>
 
-
VPIEPDTIR  </td><td>    3
 
-
</td></tr><tr><td>
 
-
LLSAFGSGD  </td><td>    3
 
-
</td></tr><tr><td>
 
-
LAKACAAEG  </td><td>    3
 
-
</td></tr><tr><td>
 
-
YSKPPQRGL </td><td>      2
 
-
</td></tr><tr><td>
 
-
YDIPGRSAV </td><td>      2
 
-
</td></tr><tr><td>
 
-
VVTPYYSKP  </td><td>    2
 
-
</td></tr><tr><td>
 
-
LPQVAATPE </td><td>      2
 
-
</td></tr><tr><td>
 
-
LEAVGDRAR  </td><td>    2
 
-
</td></tr><tr><td>
 
-
LAAGQLREL  </td><td>    2
 
-
</td></tr><table>
 
=Alergen Protein=
=Alergen Protein=

Revision as of 07:54, 5 January 2010

Immunotation of Rv2753c (dihydrodipicolinate synthase)
Name
Dihydrodipicolinate Synthase
Identifiers
Swiss Prot P63945
Genbank 888289
PDB 1XXX
Chemical data
Formula C28H37ClN4O6 [1]
Mol. wt. 30,858 Da
Pharmacokinetic data
Bioavailability  ?
Solubility  ?
Isoelectric-Point 5.57

Contents

General

dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.

This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.

Protein Sequence

>Rv2753c, TB.seq 3066222:3067121 MW:30827 VTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR

Human Homologue Blast Result

subject ids% identity% positivesalignment length evalue
sp|Q9BXD5 28 46.33 300 3.00E-023
sp|Q86XE5 26.57 46.15 286 4.00E-022
sp|Q9UG63 26.49 37.75 151 0.45
sp|O14556 22.09 50 86 2
sp|Q7Z7B0 27.69 44.62 65 2.7

Antigens

Epitopes

B-Cell Epitopes

BCEpred

Link to bcelpep  
Result Predicited by Predicited by ABCPred

ABCpred Results

Link to ABCpred
Result Predicited by Predicited by ABCPred

IEBB Analysis

Result Predicted by IEDB
Result Predicited by Predicited by IEDB

MHC Class-I Binder

Result Predicited by Predicited by nHLApred
Result Predicted by nHLApred
Result Predicited by Propred

Alergen Protein

Non Allergen Predicted by AlgPred Server

Antibacterial

Bacterial Toxin

External Links

Retrieved from "http://277988.efsst.group/drugpedia/index.php/Immunotation_of_Rv2753c_%28dihydrodipicolinate_synthase%29"