Immunotation of Rv2753c (dihydrodipicolinate synthase)
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Epitope</td><td>No of Alleles | Epitope</td><td>No of Alleles |
Revision as of 08:37, 17 December 2009
Immunotation of Rv2753c (dihydrodipicolinate synthase)
| |
Name | |
Dihydrodipicolinate Synthase | |
Identifiers | |
Swiss Prot | |
Genbank | |
PDB | |
Chemical data | |
Formula | ? |
Mol. wt. | 30,858 Da |
Pharmacokinetic data | |
Bioavailability | ? |
Solubility | ? |
Isoelectric-Point | 5.57 |
Contents |
General
dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.
This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.
Human Homologue Blast Result
subject ids | % identity | % positives | alignment length | evalue |
sp|Q9BXD5 | 28 | 46.33 | 300 | 3.00E-023 |
sp|Q86XE5 | 26.57 | 46.15 | 286 | 4.00E-022 |
sp|Q9UG63 | 26.49 | 37.75 | 151 | 0.45 |
sp|O14556 | 22.09 | 50 | 86 | 2 |
sp|Q7Z7B0 | 27.69 | 44.62 | 65 | 2.7 |
Antigens
Haptens
Epitopes
B-Cell Epitopes
PFSGDGSLDTA | |
GTTGESPTTTDGE | |
GTYDTAH | |
AEG | |
YSKPPQRGLQ | |
DATEL | |
RSAVPIEPDTIRA | |
KADLHSG | |
YSGDDALN | |
IATAR | |
GDPRLPQVAATPEQIDALAAD |
Epitope | No of Alleles |
VPIEPDTIR | 15 |
TPFSGDGSL | 14 |
TLSKAGLRL | 13 |
IEPDTIRAL | 13 |
GTYDTAHSI | 13 |
DDALNLPWL | 11 |
GFISVIAHL | 10 |
GATGFISVI | 10 |
ATPEQIDAL | 10 |
YDTAHSIRL | 9 |
GDIATARKI | 9 |
AVLEAVGDR | 9 |
ASHPNIVGV | 9 |
QRGLQAHFT | 7 |
GLQAHFTAV | 7 |
AVGDRARVI | 7 |
YSGDDALNL | 6 |
VGFDVAARL | 6 |
QLRELLSAF | 6 |
TAVADATEL | 5 |
TAARLANHL | 5 |
LLRAVLEAV | 5 |
GEKIELLRA | 5 |
DTATAARLA | 5 |
AAGQLRELL | 5 |
TDGEKIELL | 4 |
QAHFTAVAD | 4 |
MSRLGGVTL | 4 |
LDTATAARL | 4 |
HPNIVGVKD | 4 |
GVKDAKADL | 4 |
DGEKIELLR | 4 |
KIELLRAVL | 3 |
HSIRLAKAC | 3 |
GSGDIATAR | 3 |
AHLAAGQLR | 3 |
PTTTDGEKI | 2 |
IAHLAAGQL | 2 |
DLHSGAQIM | 2 |
Class-II Binder
Result predicted by NetMHCII
Epitope | No of Alleles |
TGFISVIAHLAAGQL | 6 |
GFISVIAHLAAGQLR | 6 |
PDTIRALASHPNIVG | 4 |
GATGFISVIAHLAAG | 4 |
ATGFISVIAHLAAGQ | 4 |
TELPMLLYDIPGRSA | 3 |
MGATGFISVIAHLAA | 3 |
LVVTPYYSKPPQRGL | 3 |
GQLRELLSAFGSGDI | 3 |
FISVIAHLAAGQLRE | 3 |
DTIRALASHPNIVGV | 3 |
QLRELLSAFGSGDIA | 2 |
PEQIDALAADMRAAS | 2 |
NLPWLAMGATGFISV | 2 |
LPWLAMGATGFISVI | 2 |
LNLPWLAMGATGFIS | 2 |
LLVVTPYYSKPPQRG | 2 |
LGGVTLSKAGLRLQG | 2 |
KAGLRLQGIDVGDPR | 2 |
IAGAGTYDTAHSIRL | 2 |
GLLVVTPYYSKPPQR | 2 |
GGVTLSKAGLRLQGI | 2 |
EPDTIRALASHPNIV | 2 |
ELPMLLYDIPGRSAV | 2 |
ATELPMLLYDIPGRS | 2 |
ALNLPWLAMGATGFI | 2 |
AGQLRELLSAFGSGD | 2 |
AGLRLQGIDVGDPRL | 2 |