Immunotation of Rv2753c (dihydrodipicolinate synthase)
From DrugPedia: A Wikipedia for Drug discovery
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=MHC Binder= | =MHC Binder= | ||
===Class-I Binder=== | ===Class-I Binder=== | ||
| + | <table><tr><td> | ||
| + | Epitope</td><td>No of Alleles | ||
| + | </td></tr><tr><td> | ||
| + | VPIEPDTIR 15 | ||
| + | </td></tr><tr><td> | ||
| + | TPFSGDGSL 14 | ||
| + | </td></tr><tr><td> | ||
| + | TLSKAGLRL 13 | ||
| + | </td></tr><tr><td> | ||
| + | IEPDTIRAL 13 | ||
| + | </td></tr><tr><td> | ||
| + | GTYDTAHSI 13 | ||
| + | </td></tr><tr><td> | ||
| + | DDALNLPWL 11 | ||
| + | </td></tr><tr><td> | ||
| + | GFISVIAHL 10 | ||
| + | </td></tr><tr><td> | ||
| + | GATGFISVI 10 | ||
| + | </td></tr><tr><td> | ||
| + | ATPEQIDAL 10 | ||
| + | </td></tr><tr><td> | ||
| + | YDTAHSIRL 9 | ||
| + | </td></tr><tr><td> | ||
| + | GDIATARKI 9 | ||
| + | </td></tr><tr><td> | ||
| + | AVLEAVGDR 9 | ||
| + | </td></tr><tr><td> | ||
| + | ASHPNIVGV 9 | ||
| + | </td></tr><tr><td> | ||
| + | QRGLQAHFT 7 | ||
| + | </td></tr><tr><td> | ||
| + | GLQAHFTAV 7 | ||
| + | </td></tr><tr><td> | ||
| + | AVGDRARVI 7 | ||
| + | </td></tr><tr><td> | ||
| + | YSGDDALNL 6 | ||
| + | </td></tr><tr><td> | ||
| + | VGFDVAARL 6 | ||
| + | </td></tr><tr><td> | ||
| + | QLRELLSAF 6 | ||
| + | </td></tr><tr><td> | ||
| + | TAVADATEL 5 | ||
| + | </td></tr><tr><td> | ||
| + | TAARLANHL 5 | ||
| + | </td></tr><tr><td> | ||
| + | LLRAVLEAV 5 | ||
| + | </td></tr><tr><td> | ||
| + | GEKIELLRA 5 | ||
| + | </td></tr><tr><td> | ||
| + | DTATAARLA 5 | ||
| + | </td></tr><tr><td> | ||
| + | AAGQLRELL 5 | ||
| + | </td></tr><tr><td> | ||
| + | TDGEKIELL 4 | ||
| + | </td></tr><tr><td> | ||
| + | QAHFTAVAD 4 | ||
| + | </td></tr><tr><td> | ||
| + | MSRLGGVTL 4 | ||
| + | </td></tr><tr><td> | ||
| + | LDTATAARL 4 | ||
| + | </td></tr><tr><td> | ||
| + | HPNIVGVKD 4 | ||
| + | </td></tr><tr><td> | ||
| + | GVKDAKADL 4 | ||
| + | </td></tr><tr><td> | ||
| + | DGEKIELLR 4 | ||
| + | </td></tr><tr><td> | ||
| + | KIELLRAVL 3 | ||
| + | </td></tr><tr><td> | ||
| + | HSIRLAKAC 3 | ||
| + | </td></tr><tr><td> | ||
| + | GSGDIATAR 3 | ||
| + | </td></tr><tr><td> | ||
| + | AHLAAGQLR 3 | ||
| + | </td></tr><tr><td> | ||
| + | PTTTDGEKI 2 | ||
| + | </td></tr><tr><td> | ||
| + | IAHLAAGQL 2 | ||
| + | </td></tr><tr><td> | ||
| + | DLHSGAQIM 2 | ||
| + | </td></tr><tr><td> | ||
| + | |||
===Class-II Binder=== | ===Class-II Binder=== | ||
Revision as of 06:50, 17 December 2009
| Immunotation of Rv2753c (dihydrodipicolinate synthase)
| |
| Name | |
| Dihydrodipicolinate Synthase | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | |
| Chemical data | |
| Formula | ? |
| Mol. wt. | 30,858 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 5.57 |
Contents |
General
dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.
This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|Q9BXD5 | 28 | 46.33 | 300 | 3.00E-023 |
| sp|Q86XE5 | 26.57 | 46.15 | 286 | 4.00E-022 |
| sp|Q9UG63 | 26.49 | 37.75 | 151 | 0.45 |
| sp|O14556 | 22.09 | 50 | 86 | 2 |
| sp|Q7Z7B0 | 27.69 | 44.62 | 65 | 2.7 |
