ADMET
From DrugPedia: A Wikipedia for Drug discovery
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==Absorption== | ==Absorption== | ||
| + | Drug Absorption is the process of intriducing the drug into the bloodstream. Absorption affects bioavailability—how quickly and how much of a drug reaches its target site of action. Factors that affect absorption include: | ||
| + | *method of designing and manufacturing a drug | ||
| + | *physical and chemical properties of drug | ||
| + | *physiologic characteristics of the person taking the drug | ||
| + | |||
| + | Physiologic characteristics that may affect the absorption of drugs taken by mouth include | ||
| + | *how long the stomach takes to empty | ||
| + | *what the acidity (pH) of the stomach is | ||
| + | *how quickly the drug is moved through the digestive tract | ||
==Distribution== | ==Distribution== | ||
Revision as of 03:59, 6 August 2008
ADME absorption, distribution, metabolism, and excretion, describes the disposition of a pharmaceutical compound within an organism. These four criterias influence the drug level and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug.
All xenobiotics (molecules that are alien to your body) are affected by these natural processes in the human body. Absorption determines if the drug gets into the body (passing of the gastro-intestinal tract), distribution determines if the drug can arrive at the place of action, metabolism determines whether the drug is broken down before it can arrive at place of action and excretion determines whether the drug is gone before / too soon after it can become active. ADME plays an ever increasingly important role in the drug design process.
Contents |
Absorption
Drug Absorption is the process of intriducing the drug into the bloodstream. Absorption affects bioavailability—how quickly and how much of a drug reaches its target site of action. Factors that affect absorption include:
- method of designing and manufacturing a drug
- physical and chemical properties of drug
- physiologic characteristics of the person taking the drug
Physiologic characteristics that may affect the absorption of drugs taken by mouth include
- how long the stomach takes to empty
- what the acidity (pH) of the stomach is
- how quickly the drug is moved through the digestive tract
