Capaurine

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 11:08, 10 December 2009

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Description

from root tubers of Stephania kwangsiensis H.S. Lo; RN given refers to (S)-isomer This is readily soluble in chloroform and slightly soluble in methanol and crystalize in large stout polyhedra, melting at 164⁰ C when hot methanolis added to a concentrated solution of the alkaloids in chloroform. This optically inactive and slightly soluble in chloroform. it separate from it's conc. solution in chloroform in colourless prisms melting at 408⁰C particularly if a little methanol is added.

General Properties

*Molecular Weight

371.4269

*Molecular Formula

C₂₁H₂₅NO₅

*IUPAC NAME

(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-1-ol

*Canonical Smiles

COC1=C(C2=C(CC3C4=C(C(=C(C=C4CCN3C2)OC)OC)O)C=C1)OC

*Isomeric Smiles

COC1=C(C2=C(C[C@H]3C4=C(C(=C(C=C4CCN3C2)OC)OC)O)C=C1)OC

*XLogP

2

*Topological Polar Surface Area

60.4

Source

Anomianthus dulcis

Corydalis aurea

Corydalis micrantha

Corydalis montana

Corydalis pallida

Stephania lincangensis

Function

uterine stimulant activity

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source

mouse LD50 intravenous 56mg/kg (56mg/kg) Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 5, Pg. 163, 1946.

External Links

• Pubchem

Link to BIAdb Database

Reference

Harborne,Phytochemical Dictionary Second Edition,Taylor and Francis,(1999),Chapter21