BIAdb 1-Benzylisoquinoline 1022
From DrugPedia: A Wikipedia for Drug discovery
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==Description== | ==Description== | ||
| + | '''1-Benzyl[[isoquinoline]]''' is the structural backbone of many [[alkaloid]]s with a wide variety of structures, including [[papaverine]], [[noscapine]], [[codeine]], [[morphine]], [[apomorphine]], [[berberine]], [[protopine]] and [[tubocurarine]]. | ||
| + | ==Biosynthesis== | ||
| + | Plants producing benzylisoquinoline alkaloids have a common biosynthetic pathway, making use of two units of <small>L</small>-[[tyrosine]]. One tyrosine molecule is metabolised to [[dopamine]] which constitutes the isoquinoline part, while the benzylic part is mostly formed from [[tyramine]], itself the decarboxylation product of tyrosine. | ||
| + | |||
| + | Many benzylisoquinolines have a [[methyl]]ated nitrogen atom as well as functional groups containing oxygen ([[Hydroxyl|-OH]], [[Methoxy|-OCH<sub>3</sub>]], -OCH<sub>2</sub>O-) in positions 6, 7, 3' and 4'. The latter come from the precursors mentioned above, namely tyrosine, dopamine and their derivatives. | ||
==Source== | ==Source== | ||
Revision as of 08:14, 30 November 2009
| |
| BIAdb 1-Benzylisoquinoline 1022
| |
| Systematic (IUPAC) name | |
| 1-(phenylmethyl)isoquinoline | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| ChemSpider | |
| Chemical data | |
| Formula | C16H13N |
| Mol. mass | 219.28112 |
| SMILES | & |
| Synonyms | 1-(phenylmethyl)isoquinoline |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Contents |
Description
1-Benzylisoquinoline is the structural backbone of many alkaloids with a wide variety of structures, including papaverine, noscapine, codeine, morphine, apomorphine, berberine, protopine and tubocurarine.
Biosynthesis
Plants producing benzylisoquinoline alkaloids have a common biosynthetic pathway, making use of two units of L-tyrosine. One tyrosine molecule is metabolised to dopamine which constitutes the isoquinoline part, while the benzylic part is mostly formed from tyramine, itself the decarboxylation product of tyrosine.
Many benzylisoquinolines have a methylated nitrogen atom as well as functional groups containing oxygen (-OH, -OCH3, -OCH2O-) in positions 6, 7, 3' and 4'. The latter come from the precursors mentioned above, namely tyrosine, dopamine and their derivatives.
Source
N/A
Function
Unknown
General Properties
*Molecular Weight
219.28112
*Exact Mass
219.104799
*Molecular Formula
C16H13N
*IUPAC NAME
1-(phenylmethyl)isoquinoline
*Canonical Smiles
C1=CC=C(C=C1)CC2=NC=CC3=CC=CC=C32
*Isomeric Smiles
N/A
*XLogP
4.1
*Hydrogen bond donor
0
*Hydrogen bond acceptor
1
*Rotational Bond Count
2
*Topological Polar Surface Area
12.9
