Oxycodone
From DrugPedia: A Wikipedia for Drug discovery
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| + | {{drugbox | ||
| + | | IUPAC_name = 4,5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one | ||
| + | | image = Oxycodone.png | ||
| + | | image2 = Oxycodone_3d_balls.png | ||
| + | | width = 155 | ||
| + | | CAS_number = 76-42-6 | ||
| + | | CASNo_Ref = {{cascite}} | ||
| + | | synonyms = dihydrohydroxycodeinone, 14-hydroxydihydrocodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine<ref name=MerckIndex>{{cite book|title=The Merck index|publisher=Merck & Co.|date=2006|location=Whitehouse Station, NJ|edition=14|isbn=978-0-911910-00-1}}</ref> | ||
| + | | ChemSpiderID = 4447649 | ||
| + | | ATC_prefix = N02 | ||
| + | | ATC_suffix = AA05 | ||
| + | | ATC_supplemental = <br>{{ATC|N02|AA55}} (in combinations) | ||
| + | | PubChem = 5284603 | ||
| + | | DrugBank = APRD00387 | ||
| + | | C=18 | H=21 | N=1 | O=4 | ||
| + | | molecular_weight = 315.364 g/mol | ||
| + | | smiles = COc1ccc2C[C@@H]3N(C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O | ||
| + | | bioavailability = Up to 87% | ||
| + | | protein_bound = 45% | ||
| + | | metabolism = Hepatic (CYP450: 2D6 substrate) | ||
| + | | elimination_half-life = 3 - 4.5 h | ||
| + | | pregnancy_category = B/D (prolonged use or in high doses at term) | ||
| + | | legal_AU = Schedule 8 | ||
| + | | legal_CA = Schedule I | ||
| + | | legal_UK = Class A | ||
| + | | legal_US = Schedule II | ||
| + | | legal_status = | ||
| + | | routes_of_administration = oral, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural<ref name=Kalso>{{cite journal|author=Kalso E|title=Oxycodone|journal =Journal of Pain and Symptom Management|volume=29|issue =5S|pages=S47–S56|month =May|year=2005|url=http://www.jpsmjournal.com/article/PIIS0885392405000369/fulltext}}</ref> | ||
| + | | dependency_liability = Moderate - High | ||
| + | | excretion = Urine (19% unchanged) | ||
| + | }} | ||
| + | '''Oxycodone''' is an [[opioid]] [[analgesic]] [[medication]] synthesized from opium-derived [[thebaine]]. It was developed in [[1916]] in [[Germany]], as one of several new semi-[[synthetic]] opioids with several benefits over the older traditional [[opiate]]s and opioids; [[morphine]], [[diacetylmorphine]] (heroin) and [[codeine]]. | ||
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| + | Currently it is best known as the main active ingredient in a number of oral medications commonly prescribed for the relief of moderate to severe [[pain]]. Oxycodone can be combined with inert binders (e.g., '''OxyContin'''); with [[paracetamol]], also known as acetaminophen (e.g., '''[[Percocet]]''', '''Endocet''', '''Tylox''', and '''Roxicet'''); with aspirin (e.g., '''[[Percodan]]''', '''Endodan''', '''Roxiprin'''); and with [[ibuprofen]] ('''Combunox'''). Of the oral medications containing oxycodone, OxyContin is notable for its sales; for controversies concerning its patent status and marketing; and for its potentials for hazardous use, harmful use, [[Addiction|dependence]], and [[Pharmaceutical diversion|diversion]]. | ||
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==Description== | ==Description== | ||
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Semisynthetic derivative of CODEINE that acts as a narcotic analgesic more potent and addicting than codeine. | Semisynthetic derivative of CODEINE that acts as a narcotic analgesic more potent and addicting than codeine. | ||
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| + | Oxycodone is an opioid analgesic medication synthesized from opium-derived thebaine. It was developed in 1916 in Germany, as one of several new semi-synthetic opioids with several benefits over the older traditional opiates and opioids; morphine, diacetylmorphine (heroin) and codeine. | ||
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| + | Currently it is best known as the main active ingredient in a number of oral medications commonly prescribed for the relief of moderate to severe pain. Oxycodone can be combined with inert binders (e.g., OxyContin); with paracetamol, also known as acetaminophen (e.g., Percocet, Endocet, Tylox, and Roxicet); with aspirin (e.g., Percodan, Endodan, Roxiprin); and with ibuprofen (Combunox). Of the oral medications containing oxycodone, OxyContin is notable for its sales; for controversies concerning its patent status and marketing; and for its potentials for hazardous use, harmful use, dependence, and diversion. | ||
==General Properties== | ==General Properties== | ||
Revision as of 06:55, 30 April 2009
| Oxycodone
| |
| Systematic (IUPAC) name | |
| N/A | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C18H21NO4 |
| Mol. mass | 315.36364 |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Oxycodone is an opioid analgesic medication synthesized from opium-derived thebaine. It was developed in 1916 in Germany, as one of several new semi-synthetic opioids with several benefits over the older traditional opiates and opioids; morphine, diacetylmorphine (heroin) and codeine.
Currently it is best known as the main active ingredient in a number of oral medications commonly prescribed for the relief of moderate to severe pain. Oxycodone can be combined with inert binders (e.g., OxyContin); with paracetamol, also known as acetaminophen (e.g., Percocet, Endocet, Tylox, and Roxicet); with aspirin (e.g., Percodan, Endodan, Roxiprin); and with ibuprofen (Combunox). Of the oral medications containing oxycodone, OxyContin is notable for its sales; for controversies concerning its patent status and marketing; and for its potentials for hazardous use, harmful use, dependence, and diversion.
Description
Semisynthetic derivative of CODEINE that acts as a narcotic analgesic more potent and addicting than codeine.
Oxycodone is an opioid analgesic medication synthesized from opium-derived thebaine. It was developed in 1916 in Germany, as one of several new semi-synthetic opioids with several benefits over the older traditional opiates and opioids; morphine, diacetylmorphine (heroin) and codeine.
Currently it is best known as the main active ingredient in a number of oral medications commonly prescribed for the relief of moderate to severe pain. Oxycodone can be combined with inert binders (e.g., OxyContin); with paracetamol, also known as acetaminophen (e.g., Percocet, Endocet, Tylox, and Roxicet); with aspirin (e.g., Percodan, Endodan, Roxiprin); and with ibuprofen (Combunox). Of the oral medications containing oxycodone, OxyContin is notable for its sales; for controversies concerning its patent status and marketing; and for its potentials for hazardous use, harmful use, dependence, and diversion.
General Properties
*Molecular Weight
315.36364
*Molecular Formula
C18H21NO4
*IUPAC NAME
N/A
*Canonical Smiles
CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O
*Isomeric Smiles
CN1CC[C@]23C4C(=O)CCC2([C@H]1CC5=C3C(=C(C=C5)OC)O4)O
*XLogP
0.3
*Topological Polar Surface Area
59
