5alpha-Dihydroprogesterone
From DrugPedia: A Wikipedia for Drug discovery
(Difference between revisions)
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| - | 3,20-Allopregnanedione | + | '''3,20-Allopregnanedione''' |
Pubchem(92810) | Pubchem(92810) | ||
A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR. | A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR. | ||
| - | KEGG Pathway(C03681) | + | '''KEGG Pathway'''(C03681) |
| - | C21-Steroid hormone metabolism | + | *C21-Steroid hormone metabolism |
{| border="1;width:100%; height:200px;style=text-align:center" | {| border="1;width:100%; height:200px;style=text-align:center" | ||
|+'''Physiochemical properties of Estriol:''' | |+'''Physiochemical properties of Estriol:''' | ||
Revision as of 11:36, 31 October 2008
3,20-Allopregnanedione Pubchem(92810)
A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.
KEGG Pathway(C03681)
- C21-Steroid hormone metabolism
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 200 | deg C | EXP | |
| log P (octanol-water) | 3.460 | (none) | EST | |
| Atmospheric OH Rate Constant | 3.85E-11 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | intraperitoneal | 80mg/kg (80mg/kg) | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | |
| mouse | LDLo | intravenous | 10mg/kg (10mg/kg) | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. |
