PolysacDB Lipopolysaccharide 2551
From DrugPedia: A Wikipedia for Drug discovery
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[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Vibrio cholerae 01 35 Inaba
[edit] Basic Structure
The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position
[edit] Proposed functions
V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
[edit] Antigenic Nature used to produce antibodies
Purified LPS
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab H4
[edit] Antibody type and class
IgM
[edit] Assay System
enzyme-linked immunosorbent assay inhibition experiments
[edit] Cross-reactivity
This Mab reacted with Ogawa 34 and Inaba 35 serotype LPS but did not react with O2 LPS
[edit] Proposed epitopes
This Mab was specific to A antigen. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain
[edit] Proposed Utility
This Mab had a good agglutinating capacity when tested against V. cholerae 0:1 strains
