Estriol

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'''Estriol'''
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'''Estriol''' Pubchem(5756) (also '''oestriol''') is one of the three main [[estrogen]]s produced by the human body. It is only produced in significant amounts during [[pregnancy]] as it is made by the [[placenta]]. In pregnant women with [[multiple sclerosis]] (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School. 
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Pubchem(5756)
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A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
'''Drug Type''':  Small Molecule; Approved
'''Drug Type''':  Small Molecule; Approved
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'''Pharmacology''': Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
'''Pharmacology''': Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
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*Androgen and estrogen metabolism
*Androgen and estrogen metabolism
'''Target''' estrogen receptor (ER) agonist
'''Target''' estrogen receptor (ER) agonist
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'''Activity''' Estrogen
'''Activity''' Estrogen
{| border="1;width:100%; height:200px;style=text-align:center"
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|+'''List of PDB files having estradiol as a Ligand:'''
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|+'''List of PDB files having estriol as a Ligand:'''
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|+'''Physiochemical properties of Estradiol:'''
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|+'''Physiochemical properties of Estriol:'''
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! style="background:brown; color:white" |Physical Property
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Levels of estriol in non-pregnant women do not change much after [[menopause]], and levels are not significantly different from levels in men.
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==Use in screening==
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Estriol levels can be measured to give an indication of the general health of the fetus. [[DHEA-S]] is produced by the [[adrenal cortex]] of the fetus. This is converted to estriol by the [[placenta]].
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If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a chrmosomal or congenital anomalies like [[Down's syndrome]] or [[Edward's syndrome]]. It is included as part of the [[triple test]] & [[quadrupole test]] for antenatal screening for fetal anomalies.
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Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than [[non-stress testing]]. Conditions which can create [[false-positives]] and [[false-negatives]] in estriol testing for fetal distress include [[preeclampsia]], [[anemia]] and impaired [[kidney function]].<ref>{{cite book |title=Mosby's manual of Diagnostic and Laboratory Tests, 2nd Edition |first=Kathleen |last=Deska Pagana |coauthors=Pagana, Timothy J. |year=2002}}</ref>
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==References==
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<references/>
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{{med-stub}}
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{{Sex hormones}}
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[[Category:Estrogens]]

Revision as of 08:53, 30 October 2008

Estriol Pubchem(5756) (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.

Drug Type: Small Molecule; Approved

Pharmacology: Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.

Mechanism of Action: Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of 'unconjugated estriol' are abnormally low in a pregnant woman, this may indicate a problem with the development of the child.

Indication: Used as a test to determine the general health of an unborn fetus.

KEGG Pathway(C05141,D00185)

  • Androgen and estrogen metabolism

Target estrogen receptor (ER) agonist

Activity Estrogen

List of PDB files having estriol as a Ligand:
MMDB ID PDB ID Reference
30668 1X8V Podust LM, Yermalitskaya LV, Lepesheva GI, Podust VN, Dalmasso EA, Waterman MREstriol bound and ligand-free structures of sterol 14alpha-demethylaseStructure v12, p.1937-1945
Physiochemical properties of Estriol:
Physical Property Value Units Temp (deg C) Source
Melting Point 282 deg C EXP
log P (octanol-water) 2.45 (none) EXP
Water Solubility 441 mg/L 25 EST
Vapor Pressure 1.97E-10 mm Hg 25 EST
Henry's Law Constant 1.33E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.29E-10 cm3/molecule-sec 25 EST
Toxicity:
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral > 2gm/kg (2000mg/kg) Drugs in Japan Vol. -, Pg. 176, 1990.


Levels of estriol in non-pregnant women do not change much after menopause, and levels are not significantly different from levels in men.

Use in screening

Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta.

If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a chrmosomal or congenital anomalies like Down's syndrome or Edward's syndrome. It is included as part of the triple test & quadrupole test for antenatal screening for fetal anomalies.

Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than non-stress testing. Conditions which can create false-positives and false-negatives in estriol testing for fetal distress include preeclampsia, anemia and impaired kidney function.<ref>Template:Cite book</ref>

References

<references/>

Template:Med-stub Template:Sex hormones

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