PolysacDB Lipooligosaccharide 1626

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipooligosaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Moraxella catarrhalis serotype A

[edit] Basic Structure

LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo

[edit] Proposed functions

Moracella lipooligosaccharide is a potential virulence factor

[edit] Antigenic Nature used to produce antibodies

heat inactivated Moraxella catarrhalis serotype A

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 217H4

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA, bactericidal assays and immunofluorescence assay

[edit] Cross-reactivity

This Mab was specific to serotype A

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab could be useful for the detection of M. catarrhalis and its LOS antigen in clinical samples

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database