Immunotation of Rv3459c
From DrugPedia: A Wikipedia for Drug discovery
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| PDB = 2wdh | | PDB = 2wdh | ||
| DrugBank = | | DrugBank = | ||
| - | | chemical_formula = | + | | chemical_formula = |
| molecular_weight = 147848.8 Da | | molecular_weight = 147848.8 Da | ||
| solubility = | | solubility = | ||
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}} | }} | ||
=General= | =General= | ||
| - | S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. | + | '''S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. |
| - | IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT | + | IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT''' |
Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS. | Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS. | ||
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MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA | MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA | ||
ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV | ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV | ||
| + | |||
| + | =Human Homologue Blast Result= | ||
| + | |||
| + | <table border='1'><tr> | ||
| + | |||
| + | <td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr> | ||
| + | |||
| + | <tr><td> sp|P82912.2</td><td> 44</td><td> 61</td><td> 109</td><td> 3e-15 </td></tr> | ||
| + | |||
| + | <tr><td> sp|P62263.3</td><td> 34</td><td> 58</td><td> 117</td><td> 2e-13</td></tr> | ||
| + | |||
| + | <tr><td> sp|Q9UH73.2</td><td> 27</td><td> 38</td><td> 73</td><td> 0.24</td></tr> | ||
| + | |||
| + | <tr><td> sp|Q12800.2</td><td> 26</td><td> 42</td><td> 61</td><td> 0.47</td></tr> | ||
| + | |||
| + | <tr><td> sp|Q8WW22.1</td><td> 31</td><td> 37</td><td> 58</td><td> 1.4</td></tr></table> | ||
| + | |||
| + | =Alergen Protein= | ||
| + | Link to [http://www.imtech.res.in/raghava/algpred/ Algpred]<br> | ||
Revision as of 07:18, 7 March 2010
| Immunotation of Rv3459c
| |
| Name | |
| PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | |
| Chemical data | |
| Formula | ? |
| Mol. wt. | 147848.8 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 12.22 |
Contents |
General
S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.
Protein Sequence
>Rv3459c, TB.seq 3879272:3879688 MW:14786
MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|P82912.2 | 44 | 61 | 109 | 3e-15 |
| sp|P62263.3 | 34 | 58 | 117 | 2e-13 |
| sp|Q9UH73.2 | 27 | 38 | 73 | 0.24 |
| sp|Q12800.2 | 26 | 42 | 61 | 0.47 |
| sp|Q8WW22.1 | 31 | 37 | 58 | 1.4 |
Alergen Protein
Link to Algpred
