Structural annotation of Rv2753c (dihydrodipicolinate synthase)

From DrugPedia: A Wikipedia for Drug discovery

(Difference between revisions)
Jump to: navigation, search
Line 23: Line 23:
LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI
LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI
NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
 +
 +
=PDB Structure=
 +
This protein structure is available in PDB and having code [http://www.rcsb.org/pdb/explore/explore.do?structureId=1XXX 1XXX]
=Human Homologue Blast Result=
=Human Homologue Blast Result=
Line 40: Line 43:
<tr><td>sp|Q7Z7B0</td><td> 27.69</td><td> 44.62</td><td> 65</td><td> 2.7</td></tr></table>
<tr><td>sp|Q7Z7B0</td><td> 27.69</td><td> 44.62</td><td> 65</td><td> 2.7</td></tr></table>
=Antigens=
=Antigens=
-
 
+
  =External Links=
-
No Hit Found in AntigenDB Database.<br>
+
-
 
+
-
No Hit Found in IEDB Database.<br>
+
-
 
+
-
No Hit Found in MHCBN Database.<br>
+
-
 
+
-
No Hit Found in BciPep Database.<br>
+
-
 
+
-
=Haptens=
+
-
=Epitopes=
+
-
===B-Cell Epitopes===
+
-
===MHC class I restricted T cell epitopes===
+
-
===CTL Epitopes===
+
-
=MHC Binder=
+
-
===Class-I Binder===
+
-
Result predicted by [http://www.imtech.res.in/raghava/nhlapred/comp.html nhlapred]
+
-
<table border='1'>
+
-
<tr><td>Epitope</td><td>No of Alleles
+
-
</td></tr><tr><td>
+
-
VPIEPDTIR </td><td>      15
+
-
</td></tr><tr><td>
+
-
TPFSGDGSL </td><td>    14
+
-
</td></tr><tr><td>
+
-
TLSKAGLRL  </td><td>    13
+
-
</td></tr><tr><td>
+
-
IEPDTIRAL </td><td>      13
+
-
</td></tr><tr><td>
+
-
GTYDTAHSI  </td><td>    13
+
-
</td></tr><tr><td>
+
-
DDALNLPWL </td><td>      11
+
-
</td></tr><tr><td>
+
-
GFISVIAHL  </td><td>    10
+
-
</td></tr><tr><td>
+
-
GATGFISVI  </td><td>    10
+
-
</td></tr><tr><td>
+
-
ATPEQIDAL  </td><td>    10
+
-
</td></tr><tr><td>
+
-
YDTAHSIRL  </td><td>    9
+
-
</td></tr><tr><td>
+
-
GDIATARKI  </td><td>    9
+
-
</td></tr><tr><td>
+
-
AVLEAVGDR </td><td>      9
+
-
</td></tr><tr><td>
+
-
ASHPNIVGV  </td><td>    9
+
-
</td></tr><tr><td>
+
-
QRGLQAHFT  </td><td>    7
+
-
</td></tr><tr><td>
+
-
GLQAHFTAV  </td><td>    7
+
-
</td></tr><tr><td>
+
-
AVGDRARVI  </td><td>    7
+
-
</td></tr><tr><td>
+
-
YSGDDALNL  </td><td>    6
+
-
</td></tr><tr><td>
+
-
VGFDVAARL  </td><td>    6
+
-
</td></tr><tr><td>
+
-
QLRELLSAF  </td><td>    6
+
-
</td></tr><tr><td>
+
-
TAVADATEL  </td><td>    5
+
-
</td></tr><tr><td>
+
-
TAARLANHL  </td><td>    5
+
-
</td></tr><tr><td>
+
-
LLRAVLEAV  </td><td>    5
+
-
</td></tr><tr><td>
+
-
GEKIELLRA  </td><td>    5
+
-
</td></tr><tr><td>
+
-
DTATAARLA  </td><td>    5
+
-
</td></tr><tr><td>
+
-
AAGQLRELL  </td><td>    5
+
-
</td></tr><tr><td>
+
-
TDGEKIELL  </td><td>    4
+
-
</td></tr><tr><td>
+
-
QAHFTAVAD </td><td>      4
+
-
</td></tr><tr><td>
+
-
MSRLGGVTL  </td><td>    4
+
-
</td></tr><tr><td>
+
-
LDTATAARL  </td><td>    4
+
-
</td></tr><tr><td>
+
-
HPNIVGVKD  </td><td>    4
+
-
</td></tr><tr><td>
+
-
GVKDAKADL  </td><td>    4
+
-
</td></tr><tr><td>
+
-
DGEKIELLR  </td><td>    4
+
-
</td></tr><tr><td>
+
-
KIELLRAVL  </td><td>    3
+
-
</td></tr><tr><td>
+
-
HSIRLAKAC  </td><td>    3
+
-
</td></tr><tr><td>
+
-
GSGDIATAR  </td><td>    3
+
-
</td></tr><tr><td>
+
-
AHLAAGQLR  </td><td>    3
+
-
</td></tr><tr><td>
+
-
PTTTDGEKI  </td><td>    2
+
-
</td></tr><tr><td>
+
-
IAHLAAGQL  </td><td>    2
+
-
</td></tr><tr><td>
+
-
DLHSGAQIM  </td></tr><tr><td>    2
+
-
</td></tr></table>
+
-
Result predicted by [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB]
+
-
<table border='1'><tr><td>
+
-
Epitope</td><td> No of Alleles
+
-
</td></tr><tr><td>
+
-
RVIAGAGTY </td><td>      12
+
-
</td></tr><tr><td>
+
-
IMADTGLAY  </td><td>    11
+
-
</td></tr><tr><td>
+
-
MADTGLAYY  </td><td>    7
+
-
</td></tr><tr><td>
+
-
GLQAHFTAV </td><td>      7
+
-
</td></tr><tr><td>
+
-
ATELPMLLY  </td><td>    6
+
-
</td></tr><tr><td>
+
-
ALASHPNIV  </td><td>    6
+
-
</td></tr><tr><td>
+
-
GTYDTAHSI  </td><td>    5
+
-
</td></tr><tr><td>
+
-
GLLVVTPYY  </td><td>    5
+
-
</td></tr><tr><td>
+
-
MSRLGGVTL  </td><td>    4
+
-
</td></tr><tr><td>
+
-
LLRAVLEAV  </td><td>    4
+
-
</td></tr><tr><td>
+
-
WLAMGATGF  </td><td>    3
+
-
</td></tr><tr><td>
+
-
QLRELLSAF  </td><td>    3
+
-
</td></tr><tr><td>
+
-
RALASHPNI  </td><td>    2
+
-
</td></tr><tr><td>
+
-
LLTAMVTPF  </td><td>    2
+
-
</td></tr><tr><td>
+
-
KINIAVAPL  </td><td>    2
+
-
</td></tr><tr><td>
+
-
GFISVIAHL  </td><td>    2
+
-
</td></tr></table>
+
-
 
+
-
===Class-II Binder===
+
-
 
+
-
=Alergen Protein=
+
-
Non Allergen Predicted by AlgPred Server
+
-
 
+
-
 
+
-
=External Links=
+
[[Category:C2D]]
[[Category:C2D]]
[[Category:Mtb Station]]
[[Category:Mtb Station]]

Revision as of 03:55, 30 January 2010

Structural annotation of Rv2753c (dihydrodipicolinate synthase)
Name
Dihydrodipicolinate Synthase
Identifiers
Swiss Prot P63945
Genbank 888289
PDB 1XXX
Chemical data
Formula  ?
Mol. wt. 30,858 Da
Pharmacokinetic data
Bioavailability  ?
Solubility  ?
Isoelectric-Point 5.57

Contents

General

dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.

This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.

Amino Acid Sequence of Rv2753c

>Rv2753c, TB.seq 3066222:3067121 MW:30827 VTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR

PDB Structure

This protein structure is available in PDB and having code 1XXX

Human Homologue Blast Result

subject ids% identity% positivesalignment length evalue
sp|Q9BXD5 28 46.33 300 3.00E-023
sp|Q86XE5 26.57 46.15 286 4.00E-022
sp|Q9UG63 26.49 37.75 151 0.45
sp|O14556 22.09 50 86 2
sp|Q7Z7B0 27.69 44.62 65 2.7

Antigens

=External Links=
Retrieved from "http://277988.efsst.group/drugpedia/index.php/Structural_annotation_of_Rv2753c_%28dihydrodipicolinate_synthase%29"