Immunotation of Rv2753c (dihydrodipicolinate synthase)
From DrugPedia: A Wikipedia for Drug discovery
(Difference between revisions)
| Line 38: | Line 38: | ||
=Epitopes= | =Epitopes= | ||
===B-Cell Epitopes=== | ===B-Cell Epitopes=== | ||
| + | <table> | ||
| + | <tr><td>PFSGDGSLDTA | ||
| + | </td></tr><tr><td> | ||
| + | GTTGESPTTTDGE | ||
| + | </td></tr><tr><td> | ||
| + | GTYDTAH | ||
| + | </td></tr><tr><td> | ||
| + | AEG | ||
| + | </td></tr><tr><td> | ||
| + | YSKPPQRGLQ | ||
| + | </td></tr><tr><td> | ||
| + | DATEL | ||
| + | </td></tr><tr><td> | ||
| + | RSAVPIEPDTIRA | ||
| + | </td></tr><tr><td> | ||
| + | KADLHSG | ||
| + | </td></tr><tr><td> | ||
| + | YSGDDALN | ||
| + | </td></tr><tr><td> | ||
| + | IATAR | ||
| + | </td></tr><tr><td> | ||
| + | GDPRLPQVAATPEQIDALAAD | ||
| + | </td></tr><table> | ||
===MHC class I restricted T cell epitopes=== | ===MHC class I restricted T cell epitopes=== | ||
===CTL Epitopes=== | ===CTL Epitopes=== | ||
Revision as of 06:43, 17 December 2009
| Immunotation of Rv2753c (dihydrodipicolinate synthase)
| |
| Name | |
| Dihydrodipicolinate Synthase | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | |
| Chemical data | |
| Formula | ? |
| Mol. wt. | 30,858 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 5.57 |
Contents |
General
dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H2O.
This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|Q9BXD5 | 28 | 46.33 | 300 | 3.00E-023 |
| sp|Q86XE5 | 26.57 | 46.15 | 286 | 4.00E-022 |
| sp|Q9UG63 | 26.49 | 37.75 | 151 | 0.45 |
| sp|O14556 | 22.09 | 50 | 86 | 2 |
| sp|Q7Z7B0 | 27.69 | 44.62 | 65 | 2.7 |
