Roemerine
From DrugPedia: A Wikipedia for Drug discovery
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==Description== | ==Description== | ||
from root tubers of Stephania kwangsiensis H.S. Lo; RN given refers to (R)-isomer; synonym aporeine refers to (S)-isomer; structure in Merck Index, 9th ed, #779 | from root tubers of Stephania kwangsiensis H.S. Lo; RN given refers to (R)-isomer; synonym aporeine refers to (S)-isomer; structure in Merck Index, 9th ed, #779 | ||
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+ | (-)-roemerine, isolated from the leaves of Annona senegalensis, was found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB-V1 cells. | ||
==General Properties== | ==General Properties== |
Current revision
Roemerine
| |
Systematic (IUPAC) name | |
N/A | |
Identifiers | |
CAS number | ? |
ATC code | ? |
PubChem | |
Chemical data | |
Formula | C18H17NO2 |
Mol. mass | 279.33308 |
SMILES | & |
Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | ? |
Half life | ? |
Excretion | ? |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status | |
Routes | ? |
[edit] Description
from root tubers of Stephania kwangsiensis H.S. Lo; RN given refers to (R)-isomer; synonym aporeine refers to (S)-isomer; structure in Merck Index, 9th ed, #779
(-)-roemerine, isolated from the leaves of Annona senegalensis, was found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB-V1 cells.
[edit] General Properties
*Molecular Weight
279.33308
*Molecular Formula
C18H17NO2
*IUPAC NAME
N/A
*Canonical Smiles
CN1CCC2=CC3=C(C4=C2C1CC5=CC=CC=C54)OCO3
*Isomeric Smiles
CN1CCC2=CC3=C(C4=C2[C@H]1CC5=CC=CC=C54)OCO3
*XLogP
3.3
*Topological Polar Surface Area
21.7