Obestatin-23
From DrugPedia: A Wikipedia for Drug discovery
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==Description== | ==Description== | ||
Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin-23; Obestatin-13]. | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin-23; Obestatin-13]. | ||
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59301 | 59301 | ||
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Current revision
Contents |
[edit] Description
Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin-23; Obestatin-13].
[edit] Source Organism
Rattus norvegicus (Rat).
[edit] Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
[edit] Subcellular Localization
Secreted protein.
[edit] Developmental Stage
[edit] Similarity
Belongs to the motilin family.
[edit] Post translational Modification
O-n-octanoylation is essential for ghrelin activity. The replacement of Ser-26 by aromatic tryptophan preserves ghrelin activity. Amidation of Leu-98 is essential for obestatin activity.
[edit] Function
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
[edit] GeneID
59301
