Drugs in clinical trial

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(New page: A table showing drug in clinical trial for alzheimer's diasease {| |Name |OTHER NAMES FDA PHASE NAME: AAB-001 OTHER NAMES: Bapineuzumab, Humanized monoclonal anti-Aβ antibody FDA PHAS...)
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A table showing drug in clinical trial for alzheimer's diasease
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{{Refimprove|date=August 2008}}
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{|
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A table showing drug in clinical trial for Alzheimer's disease
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|Name
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{| border="1;width:100%; height:200px;style=text-align:center"
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|OTHER NAMES
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|+'''Table I:'''
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FDA PHASE
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|-
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NAME: [[AAB-001]]
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! style="background:brown; color:white" |Name
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OTHER NAMES: Bapineuzumab, Humanized monoclonal anti-Aβ antibody
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! style="background:brown; color:white" |OTHER NAMES
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FDA PHASE: Phase III
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! style="background:brown; color:white" |FDA PHASE
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+
|-
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NAME: ACC-001
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|AAB-001
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FDA PHASE: Phase I
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|Bapineuzumab, Humanized monoclonal anti-Aβ antibody
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+
|Phase III
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NAME: Acetyl-l-carnitine HCI
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|-
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OTHER NAMES: ALCAR
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|ACC-001
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FDA PHASE: Discontinued
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|
-
 
+
|Phase I
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NAME: AF 102B
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|-
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OTHER NAMES: cevimeline HCL, Evoxac™
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|Acetyl-l-carnitine HCI
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FDA PHASE: Discontinued
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|ALCAR
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|Discontinued
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NAME: Alpha-tocopherol
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|-
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OTHER NAMES: Vitamin E
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|AF 102B
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|cevimeline HCL, Evoxac™
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NAME: Alzhemed™
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|Discontinued
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OTHER NAMES:  3-amino-1-propanesulfonic acid, 3-aminopropylsulfonic acid, 3-APS, homotaurine, NC-531, Tramiprosate
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|-
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FDA PHASE: Phase III
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|Alpha-tocopherol
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|Vitamin E
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NAME: AN 1792
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|Discontinued
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OTHER NAMES: AIP 001
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|-
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FDA PHASE: Discontinued
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|Alzhemed™
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|3-amino-1-propanesulfonic acid, 3-aminopropylsulfonic acid, 3-APS, homotaurine, NC-531, Tramiprosate
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NAME: Atorvastatin
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|Phase III
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OTHER NAMES: Lipitor™
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|-
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FDA PHASE: Phase II/IIa/IIb
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|AN 1792
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|AIP 001
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NAME: AZD3480
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|Discontinued
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OTHER NAMES: ispronicline, TC-1734
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|-
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FDA PHASE: Phase II/IIa/IIb
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|Atorvastatin
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|Lipitor™
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NAME: Besipirdine HCl
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|Phase II/IIa/IIb
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OTHER NAMES: HP 749
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|-
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FDA PHASE: Discontinued
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|AZD3480
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+
|ispronicline, TC-1734
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NAME: Beta- & Gamma-Secretase Inhibitors
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|Phase II/IIa/IIb
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FDA PHASE: Preclinical
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|-
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|Besipirdine HCl
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NAME: Cerebrolysin
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|HP 749
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FDA PHASE: Approved outside U.S.
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|Discontinued
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|-
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NAME: Clioquinol
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|Beta- & Gamma-Secretase Inhibitors
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OTHER NAMES: iodochlorhydroxyquin, PBT-1
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|
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FDA PHASE: Discontinued
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|Preclinical
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|-
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NAME: COGNIShunt™
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|Cerebrolysin
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FDA PHASE: Phase II/IIa/IIb
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|
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|Approved outside U.S.
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NAME: CX516
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|-
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OTHER NAMES: Ampalex
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|Clioquinol
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FDA PHASE: Phase II/IIa/IIb
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|iodochlorhydroxyquin, PBT-1
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+
|Discontinued
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NAME: Dapsone
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|-
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OTHER NAMES: Avlosulfon
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|COGNIShunt™
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FDA PHASE: Phase II/IIa/IIb
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|
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|Phase II/IIa/IIb
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NAME: Dimebon
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|-
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OTHER NAMES: 3,6-dimethyl-9-(2-methyl-pyridyl-5)-ethyl-1,2,3,4-tetrahydro-γ-carboline dihydrochloride
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|CX516
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FDA PHASE: Phase II/IIa/IIb
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|Ampalex
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|Phase II/IIa/IIb
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|-
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NAME: Docosahexanoic acid (DHA)
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|Dapsone
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OTHER NAMES: Omega 3 fatty acids
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|Avlosulfon
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FDA PHASE: Phase III
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|Phase II/IIa/IIb
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|-
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NAME: Donepezil
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|Dimebon
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OTHER NAMES: Aricepts™
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|3,6-dimethyl-9-(2-methyl-pyridyl-5)-ethyl-1,2,3,4-tetrahydro-γ-carboline dihydrochloride
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FDA PHASE: FDA approved
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|Phase II/IIa/IIb
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MECHANISMS: cholinesterase inhibitors
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|-
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ROLE IN ALZHEIMER'S DISEASE: Improves cognition, global function, and activities of daily living.
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|Docosahexanoic acid (DHA)
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|Omega 3 fatty acids
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|Phase III
 +
|-
 +
|Donepezil
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|Aricepts™
 +
|FDA approved
 +
|-
 +
|Eptastigmine
 +
|MF 201
 +
|Discontinued
 +
|-
 +
|Estrogen
 +
|Premarin™
 +
|Phase III
 +
|-
 +
|Exelon™
 +
|Rivastigmine tartrate
 +
|FDA approved
 +
|-
 +
|Flurizan™
 +
|MPC-7869, r-flurbiprofen, tarenflurbil
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|Discontinued
 +
|-
 +
|Galantamine
 +
|Reminyl™
 +
|FDA approved
 +
|-
 +
|Huperzine A
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|Cerebra capsule, Pharmassure Memorall capsule
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|Phase II/IIa/IIb
 +
|-
 +
|Ibuprofen
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|Advil™, Motrin™, Nuprin™
 +
|Phase III
 +
|-
 +
|Idebenone
 +
|
 +
|Discontinued
 +
|-
 +
|Intravenous Immunoglobulin
 +
|IVIg
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|Phase II/IIa/IIb
 +
|-
 +
|Leuprolide
 +
|Leuprolide acetate
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|Phase III
 +
|-
 +
|Linopirdine
 +
|DuP996
 +
|Discontinued
 +
|-
 +
|LU25-109
 +
|
 +
|Discontinued
 +
|-
 +
|LY450139 Dihydrate
 +
|hydroxylvaleryl monobenzocaprolactam
 +
|Phase III
 +
|-
 +
|Melatonin
 +
|
 +
|Not FDA regulated
 +
|-
 +
|MEM 1003
 +
|
 +
|Phase II/IIa/IIb
 +
|-
 +
|Memantine
 +
|Ebixa™, Namenda™
 +
|FDA approved
 +
|-
 +
|Metrifonate
 +
|
 +
|Discontinued
 +
|-
 +
|Milameline
 +
|CI 979
 +
|
 +
|-
 +
|MKC-231
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|
 +
|Phase II/IIa/IIb
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|-
 +
|NAME: Naproxen
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|Aleve™, Anaprox™, Naprosyn™
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|Phase III
 +
|-
 +
|Nefiracetam
 +
|
 +
|Phase II/IIa/IIb
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|-
 +
|NeoTrofin
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|AIT-082
 +
|Phase II/III
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|-
 +
|Neramexane
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|1-amino-1,3,3,5,5-pentamethyl-cyclohexane hydrochloride, MRZ 2/579
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|Phase III
 +
|-
 +
|Nerve Growth Factor Gene Therapy
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|Nerve Growth Factor
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|Phase II/IIa/IIb
 +
|-
 +
|NGX267
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|AF267B
 +
|Phase I
 +
|-
 +
|NS2330
 +
|
 +
|Phase II/IIa/IIb
 +
|-
 +
|PBT2
 +
|
 +
|Phase II/IIa/IIb
 +
|-
 +
|Phenserine
 +
|
 +
|Inactive
 +
|-
 +
|Physostigmine Salicylate
 +
|Synapton
 +
|Discontinued
 +
|-
 +
|Propentofylline
 +
|
 +
|HWA 285
 +
|-
 +
|PRX-0314
 +
|7-isopropyl-6-oxo-5(3-piperidin-1-yl-propylcarbamoyl)-6,7-dihydro-thieno[2,3-b]pyridine-4-olate, potassium salt
 +
|Phase I
 +
|-
 +
|Rofecoxib
 +
|Vioxx™
 +
|Phase III
 +
|-
 +
|Rosiglitazone
 +
|5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione, AVANDIA®, Rosiglitazone maleate
 +
|Phase III
 +
|-
 +
|Sabeluzole
 +
|R58735
 +
|Discontinued
 +
|-
 +
|SB 202026
 +
|Memric, Sabcomeline
 +
|Discontinued
 +
|-
 +
|SGS-742
 +
|CGP-36742, DVD-742
 +
|Phase II/IIa/IIb
 +
|-
 +
|Simvastatin
 +
|Zocor®
 +
|Phase III
 +
|-
 +
|Statins
 +
|
 +
|Phase II/IIa/IIb
 +
|-
 +
|Suritozole
 +
|MD 26,479
 +
|Discontinued
 +
|-
 +
|Tacrine
 +
|Cognex™
 +
|FDA approved
 +
|-
 +
|Valproate
 +
|Depakene (valproic acid or sodium valproate), Depakote (divalproex sodium)
 +
|Phase III
 +
|-
 +
|}

Current revision

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A table showing drug in clinical trial for Alzheimer's disease

Table I:
Name OTHER NAMES FDA PHASE
AAB-001 Bapineuzumab, Humanized monoclonal anti-Aβ antibody Phase III
ACC-001 Phase I
Acetyl-l-carnitine HCI ALCAR Discontinued
AF 102B cevimeline HCL, Evoxac™ Discontinued
Alpha-tocopherol Vitamin E Discontinued
Alzhemed™ 3-amino-1-propanesulfonic acid, 3-aminopropylsulfonic acid, 3-APS, homotaurine, NC-531, Tramiprosate Phase III
AN 1792 AIP 001 Discontinued
Atorvastatin Lipitor™ Phase II/IIa/IIb
AZD3480 ispronicline, TC-1734 Phase II/IIa/IIb
Besipirdine HCl HP 749 Discontinued
Beta- & Gamma-Secretase Inhibitors Preclinical
Cerebrolysin Approved outside U.S.
Clioquinol iodochlorhydroxyquin, PBT-1 Discontinued
COGNIShunt™ Phase II/IIa/IIb
CX516 Ampalex Phase II/IIa/IIb
Dapsone Avlosulfon Phase II/IIa/IIb
Dimebon 3,6-dimethyl-9-(2-methyl-pyridyl-5)-ethyl-1,2,3,4-tetrahydro-γ-carboline dihydrochloride Phase II/IIa/IIb
Docosahexanoic acid (DHA) Omega 3 fatty acids Phase III
Donepezil Aricepts™ FDA approved
Eptastigmine MF 201 Discontinued
Estrogen Premarin™ Phase III
Exelon™ Rivastigmine tartrate FDA approved
Flurizan™ MPC-7869, r-flurbiprofen, tarenflurbil Discontinued
Galantamine Reminyl™ FDA approved
Huperzine A Cerebra capsule, Pharmassure Memorall capsule Phase II/IIa/IIb
Ibuprofen Advil™, Motrin™, Nuprin™ Phase III
Idebenone Discontinued
Intravenous Immunoglobulin IVIg Phase II/IIa/IIb
Leuprolide Leuprolide acetate Phase III
Linopirdine DuP996 Discontinued
LU25-109 Discontinued
LY450139 Dihydrate hydroxylvaleryl monobenzocaprolactam Phase III
Melatonin Not FDA regulated
MEM 1003 Phase II/IIa/IIb
Memantine Ebixa™, Namenda™ FDA approved
Metrifonate Discontinued
Milameline CI 979
MKC-231 Phase II/IIa/IIb
NAME: Naproxen Aleve™, Anaprox™, Naprosyn™ Phase III
Nefiracetam Phase II/IIa/IIb
NeoTrofin AIT-082 Phase II/III
Neramexane 1-amino-1,3,3,5,5-pentamethyl-cyclohexane hydrochloride, MRZ 2/579 Phase III
Nerve Growth Factor Gene Therapy Nerve Growth Factor Phase II/IIa/IIb
NGX267 AF267B Phase I
NS2330 Phase II/IIa/IIb
PBT2 Phase II/IIa/IIb
Phenserine Inactive
Physostigmine Salicylate Synapton Discontinued
Propentofylline HWA 285
PRX-0314 7-isopropyl-6-oxo-5(3-piperidin-1-yl-propylcarbamoyl)-6,7-dihydro-thieno[2,3-b]pyridine-4-olate, potassium salt Phase I
Rofecoxib Vioxx™ Phase III
Rosiglitazone 5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione, AVANDIA®, Rosiglitazone maleate Phase III
Sabeluzole R58735 Discontinued
SB 202026 Memric, Sabcomeline Discontinued
SGS-742 CGP-36742, DVD-742 Phase II/IIa/IIb
Simvastatin Zocor® Phase III
Statins Phase II/IIa/IIb
Suritozole MD 26,479 Discontinued
Tacrine Cognex™ FDA approved
Valproate Depakene (valproic acid or sodium valproate), Depakote (divalproex sodium) Phase III
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