5alpha-Dihydroprogesterone
From DrugPedia: A Wikipedia for Drug discovery
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| - | 3,20-Allopregnanedione | + | '''3,20-Allopregnanedione''' |
Pubchem(92810) | Pubchem(92810) | ||
A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR. | A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR. | ||
| - | KEGG Pathway(C03681) | + | '''KEGG Pathway'''(C03681) |
| - | C21-Steroid hormone metabolism | + | *C21-Steroid hormone metabolism |
{| border="1;width:100%; height:200px;style=text-align:center" | {| border="1;width:100%; height:200px;style=text-align:center" | ||
| - | |+'''Physiochemical properties of | + | |+'''Physiochemical properties of 5alpha-Dihydroprogesterone:''' |
|- | |- | ||
! style="background:brown; color:white" |Physical Property | ! style="background:brown; color:white" |Physical Property | ||
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|EST | |EST | ||
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| - | + | |} | |
| - | Organism | + | {| border="1;width:100%; height:200px;style=text-align:center" |
| + | |+'''Toxicity:''' | ||
| + | |- | ||
| + | ! style="background:brown; color:white" |Organism | ||
| + | ! style="background:brown; color:white" |Test Type | ||
| + | ! style="background:brown; color:white" |Route | ||
| + | ! style="background:brown; color:white" |Reported Dose (Normalized Dose) | ||
| + | ! style="background:brown; color:white" |Effect | ||
| + | ! style="background:brown; color:white" |Source | ||
| + | |- | ||
|mouse | |mouse | ||
|LDLo | |LDLo | ||
|intraperitoneal | |intraperitoneal | ||
| - | |80mg/kg (80mg/kg) | + | |80mg/kg (80mg/kg) |
| + | | | ||
|Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | |Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | ||
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| Line 44: | Line 54: | ||
|LDLo | |LDLo | ||
|intravenous | |intravenous | ||
| - | |10mg/kg (10mg/kg) | + | |10mg/kg (10mg/kg) |
| + | | | ||
|Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | |Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | ||
|- | |- | ||
Current revision
3,20-Allopregnanedione Pubchem(92810)
A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.
KEGG Pathway(C03681)
- C21-Steroid hormone metabolism
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 200 | deg C | EXP | |
| log P (octanol-water) | 3.460 | (none) | EST | |
| Atmospheric OH Rate Constant | 3.85E-11 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | intraperitoneal | 80mg/kg (80mg/kg) | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | |
| mouse | LDLo | intravenous | 10mg/kg (10mg/kg) | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. |
