Cortisol

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(New page: Hydrocortisone(Cortisol) Pubchem(5754) The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of...)
Current revision (09:07, 24 October 2008) (edit) (undo)
 
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Hydrocortisone(Cortisol)
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'''Hydrocortisone(Cortisol)'''
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Pubchem(5754)
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'''Pubchem(5754)'''
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
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0 POOR
0 POOR
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Pathway(C00735,D00088)   
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'''KEGG Pathway'''(C00735,D00088)   
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C21-Steroid hormone metabolism
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*C21-Steroid hormone metabolism
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Neuroactive ligand-receptor interaction
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*Neuroactive ligand-receptor interaction
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Prostate cancer
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*Prostate cancer
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Target glucocorticoid receptor
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'''Target''' glucocorticoid receptor
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Activity Glucocorticoid
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'''Activity''' Glucocorticoid
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{| border="1;width:100%; height:200px;style=text-align:center"
 +
|+'''Table I:'''
 +
|-
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! style="background:brown; color:white" |MMDB ID
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! style="background:brown; color:white" |PDB ID
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! style="background:brown; color:white" |Reference
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|-
|59369
|59369
|2Q1V
|2Q1V
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|-
|-
|}
|}
-
 
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{| border="1;width:100%; height:200px;style=text-align:center"
 +
|+'''Table I:'''
 +
|-
 +
! style="background:brown; color:white" |Physical Property
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! style="background:brown; color:white" |Value
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! style="background:brown; color:white" |Units
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! style="background:brown; color:white" |Temp (deg C)
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! style="background:brown; color:white" |Source
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|-
|Melting Point
|Melting Point
|220
|220
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|320
|320
|mg/L
|mg/L
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|25
+
|25
|EXP
|EXP
|-
|-
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|5.77E-08
|5.77E-08
|atm-m3/mole
|atm-m3/mole
-
|25
+
|25
|EST
|EST
|-
|-
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|1.14E-10
|1.14E-10
|cm3/molecule-sec
|cm3/molecule-sec
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|25
+
|25  
|EST
|EST
|-
|-
-
 
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|}
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Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
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{| border="1;width:100%; height:200px;style=text-align:center"
 +
|+'''Table I:'''
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|-
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! style="background:brown; color:white" |Organism  
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! style="background:brown; color:white" |Test Type
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! style="background:brown; color:white" |Route
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! style="background:brown; color:white" |Reported Dose (Normalized Dose)
 +
! style="background:brown; color:white" |Effect
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! style="background:brown; color:white" |Source
 +
|-
|man
|man
|TDLo
|TDLo
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|LD50
|LD50
|subcutaneous
|subcutaneous
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|> 500mg/kg (500mg/kg)  
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|> 500mg/kg (500mg/kg)  
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|  
|Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990.
|Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990.
 +
|-
|rat
|rat
|LD50
|LD50
|intraperitoneal
|intraperitoneal
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|150mg/kg (150mg/kg)  
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|150mg/kg (150mg/kg)  
 +
|  
|Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971.
|Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971.
|-
|-
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|LD50
|LD50
|subcutaneous
|subcutaneous
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|449mg/kg (449mg/kg)  
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|449mg/kg (449mg/kg)  
 +
|  
|Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
|Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
|-
|-
|}
|}

Current revision

Hydrocortisone(Cortisol)

Pubchem(5754)

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Lipinski’s “Rule of Five” Prediction for a Compound’s ABSORPTION OR PERMEABILITY PROPERTIES 4 GOOD 3 INDETERMINATE 2 INDETERMINATE 1 INDETERMINATE 0 POOR

KEGG Pathway(C00735,D00088)

  • C21-Steroid hormone metabolism
  • Neuroactive ligand-receptor interaction
  • Prostate cancer

Target glucocorticoid receptor

Activity Glucocorticoid

Table I:
MMDB ID PDB ID Reference
59369 2Q1V Ortlund EA, Bridgham JT, Redinbo MR, Thornton JWCrystal structure of an ancient protein: evolution by conformational epistasisScience v317, p.1544-1548
59811 2V95 Klieber MA, Underhill C, Hammond GL, Muller YACorticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered releaseJ. Biol. Chem. v282, p.29594-29603
64401 2VDY Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RWThe S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone releaseJ. Mol. Biol. v380, p.244-251
Table I:
Physical Property Value Units Temp (deg C) Source
Melting Point 220 deg C EXP
Water Solubility 320 mg/L 25 EXP
Vapor Pressure 1.35E-13 mm Hg 25 EST
Henry's Law Constant 5.77E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.14E-10 cm3/molecule-sec 25 EST
Table I:
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 400mg/kg/10D- (400mg/kg) BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS Psychopharmacology Vol. 145, Pg. 260, 1999.
mouse LD50 subcutaneous > 500mg/kg (500mg/kg) Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990.
rat LD50 intraperitoneal 150mg/kg (150mg/kg) Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971.
rat LD50 subcutaneous 449mg/kg (449mg/kg) Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
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