Amrinone
From DrugPedia: A Wikipedia for Drug discovery
(New page: '''Amrinone''' (INN) or '''inamrinone''', trade name '''Inocor''', is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. ==Class== Ca...) |
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'''Amrinone''' (INN) or '''inamrinone''', trade name '''Inocor''', is a type 3 pyridine phosphodiesterase inhibitor. | '''Amrinone''' (INN) or '''inamrinone''', trade name '''Inocor''', is a type 3 pyridine phosphodiesterase inhibitor. | ||
Current revision
Amrinone (INN) or inamrinone, trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor.
It is used in the treatment of congestive heart failure.
Contents |
[edit] Class
Cardiac inotrope.
[edit] Actions
Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP
[edit] Indications
Short-term management of severe CHF.
[edit] Contraindications
Patients with history of hypersensitivity to the drug.
[edit] Precautions
May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.
[edit] Side effects
Reduction in platelets, nausea and vomiting cardiac arrhythmias.
[edit] Routes
IV bolus and infusion as described earlier.
[edit] Pediatric dosage
Safety in children has not been established
