PolysacDB Phenolic glycolipid antigen 1636

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Phenolic glycolipid antigen

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Mycobacterium leprae

[edit] Basic Structure

It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose

[edit] Proposed functions

It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells

[edit] Antigenic Nature used to produce antibodies

Partially purified phenolic glycolipid from M. leprae

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab A3H

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, TLC autoradiography and immunofluorescence

[edit] Cross-reactivity

This Mab was specific to M. leprae glycolipid

[edit] Proposed epitopes

Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope

[edit] Proposed Utility

This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database