CarboDB 2473
From DrugPedia: A Wikipedia for Drug discovery
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[edit] Carbohydrate Name
Excretory-secretory antigen [ES]
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Toxocara canis
[edit] Basic Structure
Excretory-secretory (ES) antigens of this species are composed of a restricted range of components, with overlapping but not identical profiles. The ES antigens range in m.w. from 32,000 (32 KDa) to 400 KDa and include at least one allergenic component. They are each glycoproteins, containing in all 40% by weight of carbohydrate, and differential lectin binding and protease sensitivity indicate that the major components are discrete parasite antigens rather than degradation products of common derivation
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
T. canis larvae
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Tcn-2
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, immunoblotting, immunofluorescence, Immunoradiometric assay and inhibition assay
[edit] Cross-reactivity
This Mab was specific to Toxocara canis and did not react with surface-labeled antigens of the nematodes T.spiralis, Heligmososmoides polygyrus. or B. pahangi
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab was able to bind to exposed sites on the epicuticle of intact Toxocara larvae
