CarboDB Capsular polysaccharide 1807

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 00:00, 15 January 2001 (edit) Special:Contributions/ (Talk) ← Previous diff

Current revision (06:09, 8 April 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Neisseria meningitidis group B

[edit] Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

[edit] Proposed functions

It is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 30H12

[edit] Antibody type and class

IgG2a

[edit] Assay System

ELISA and bactericidal assays

[edit] Cross-reactivity

This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab did not recognized N-propionylated capsular polysaccharide of group B meningitidis

[edit] Proposed epitopes

α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope

[edit] Proposed Utility

This Mab had potent bactericidal activity

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• Link to CarboDB database