Moraxella catarrhalis
From DrugPedia: A Wikipedia for Drug discovery
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'''Moraxella catarrhalis''' | '''Moraxella catarrhalis''' | ||
| + | It is a Gram-negative, aerobic, oxidase-positive diplococcus that may both colonize and cause respiratory tract-associated infection in humans. | ||
| + | {| border="1" style="text-align: left;" | ||
| + | |+ '''Scientific classification''' | ||
| + | !Kingdom || Bacteria | ||
| + | |- | ||
| + | ! Phylum || Proteobacteria | ||
| + | |- | ||
| + | ! Class || Gammaproteobacteria | ||
| + | |- | ||
| + | ! Order || Pseudomonadales | ||
| + | |- | ||
| + | ! Family || Moraxellaceae | ||
| + | |- | ||
| + | ! Genus || Moraxella | ||
| + | |- | ||
| + | ! Species || '''''M. catarrhalis''''' | ||
| + | |- | ||
| + | ! Binomial || ''Moraxella catarrhalis'' | ||
| + | |} | ||
| + | ==Surface Characteristics== | ||
| + | The LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo[ branched to Kdop-(2-?)] | ||
| + | ==Pathogenic Activity== | ||
| + | These bacteria are known to cause otitis media, bronchitis, sinusitis, and laryngitis. Elderly patients and long-term heavy smokers with chronic pulmonary disease should be aware that M. catarrhalis is associated with bronchopneumonia, as well as exacerbations of existing chronic obstructive pulmonary disease (COPD). | ||
| + | ==Virulence== | ||
| + | Lipooligosaccharide is considered one possible virulence factor. The great majority of clinical isolates of this organism produce beta-lactamases and are resistant to penicillin. Resistance to trimethoprim, trimethoprim-sulfamethoxazole (TMP-SMX) and tetracycline have been reported. It is susceptible to fluoroquinolones, most second and third generation cephalosporins, erythromycin and amoxicillin-clavulanate. | ||
| + | ==References== | ||
| + | [http://en.wikipedia.org/wiki/Moraxella_catarrhalis Wikipedia] | ||
| - | [[category: | + | [[category:PolysacDB]] |
Current revision
Moraxella catarrhalis
It is a Gram-negative, aerobic, oxidase-positive diplococcus that may both colonize and cause respiratory tract-associated infection in humans.
| Kingdom | Bacteria |
|---|---|
| Phylum | Proteobacteria |
| Class | Gammaproteobacteria |
| Order | Pseudomonadales |
| Family | Moraxellaceae |
| Genus | Moraxella |
| Species | M. catarrhalis |
| Binomial | Moraxella catarrhalis |
Contents |
[edit] Surface Characteristics
The LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo[ branched to Kdop-(2-?)]
[edit] Pathogenic Activity
These bacteria are known to cause otitis media, bronchitis, sinusitis, and laryngitis. Elderly patients and long-term heavy smokers with chronic pulmonary disease should be aware that M. catarrhalis is associated with bronchopneumonia, as well as exacerbations of existing chronic obstructive pulmonary disease (COPD).
[edit] Virulence
Lipooligosaccharide is considered one possible virulence factor. The great majority of clinical isolates of this organism produce beta-lactamases and are resistant to penicillin. Resistance to trimethoprim, trimethoprim-sulfamethoxazole (TMP-SMX) and tetracycline have been reported. It is susceptible to fluoroquinolones, most second and third generation cephalosporins, erythromycin and amoxicillin-clavulanate.
