Serotonin
From DrugPedia: A Wikipedia for Drug discovery
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Revision as of 06:27, 5 November 2008
Serotonin Pubchem(5202)
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
KEGG Pathway(C00780)
- Tryptophan metabolism
- Neuroactive ligand-receptor interaction
- Gap junction
- Serotonin receptor agonists/antagonists
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 59445 | 2QEH | Mans BJ, Calvo E, Ribeiro JM, Andersen JFThe Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiaeJ. Biol. Chem. v282, p.36626-36633 |
| 63512 | 3BRN | Mans BJ, Ribeiro JM, Andersen JFStructure, function, and evolution of biogenic amine-binding proteins in soft ticksJ. Biol. Chem. v283, p.18721-18733 |
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 167.5 | deg C | EXP | |
| pKa Dissociation Constant | 9.97 | (none) | 25 | EXP |
| log P (octanol-water) | 0.21 | (none) | EXP | |
| Water Solubility | 2.00E+04 | mg/L | 27 | EXP |
| Vapor Pressure | 1.91E-06 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.39E-14 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.33E-10 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 5mg/kg (5mg/kg) | CARDIAC: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. | |
| guinea pig | LD50 | intravenous | 12800ug/kg (12.8mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 168, Pg. 373, 1967. | |
| mouse | LD50 | intramuscular | 750mg/kg (750mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 112, Pg. 319, 1957. | |
| mouse | LD50 | intraperitoneal | 160mg/kg (160mg/kg) | Indian Journal of Physiology and Pharmacology. Vol. 17, Pg. 31, 1973. | |
| mouse | LD50 | intravenous | 81mg/kg (81mg/kg) | BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. | |
| mouse | LD50 | oral | 60mg/kg (60mg/kg) | Meditsinskii Zhurnal Uzbekistana. Vol. (3), Pg. 61, 1985. | |
| mouse | LD50 | subcutaneous | 601mg/kg (601mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Farmakologiya i Toksikologiya Vol. 26, Pg. 10, 1963. |
| mouse | LD50 | unreported | 250mg/kg (250mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 122, 1982. | |
| rat | LD50 | intravenous | 30mg/kg (30mg/kg) | Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963. | |
| rat | LD50 | subcutaneous | 285mg/kg (285mg/kg) | Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963. |
