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                                          '''Where are we standing?????????????????????'''
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Consult the [http://meta.wikimedia.org/wiki/Help:Contents User's Guide] and [[manual:FAQ|FAQ]] for information on using the wiki software.
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After 126 years, the etiological agent of deadly tuberculosis (http://en.wikipedia.org/wiki/Tuberculosis) has been discovered by Robert Koch, we have only one vaccine and few countable antibiotics against tuberculosis. Is this justifiable?
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Recent estimates of Tuberculosis disease is approximately 1.86 billion people with 16.2 million cases of active diseases. (Dye etal.,1999). It’s a fact and I also support that not a single treatment but a combinatorial approach is required against this culprit. We are living in the age of biotechnology and Nanotechnology so we should look for molecular medicine which may be some involve synthetic  molecules mimicking that in system approaches.  Through this article I have tried to make people think about the computers, biomolecules and some naturally occurring compounds as a combinatorial approach to fight the evil like tuberculosis.  
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==DrugPedia: A Wikipedia for Drug Discovery ==
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*Drugpedia is a wikipedia created for collecting and compiling information related to computer-aided drug design.
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*The aim of Drugpedia is to provide comprehensive information about drugs.  
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*Drugpedia is developed under the umbrella of [http://www.osdd.net/ Open Source Drug Discovery (OSDD)] project.
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*Dudpedia covers wide range of subjects around drugs like Bioinformatics, Cheminfiormatics, clinical informatics etc.
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==Virtual Summer Trainees==
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Students often find it difficult to get placements for training (short/long/summer training), which is mandatory requirement for getting a degree. The Drugpedia provide opportunity for students to take small projects related to information collection and compilation. We may issue a certificate for students who contribute significantly to Drugpedia (at least 10 important articles).   
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==Important databases and Projects==
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[http://crdd.osdd.net/drugpedia/index.php/Category:Mtb_Station Mtb_Station] :  '''M'''ycobacterium '''t'''u'''b'''erculosis '''S'''tructural Anno'''tation''
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In my this article I am suggesting one of my idea although its very older approach which has been discovered in 20th century that is Antisense DNA technology (http://en.wikipedia.org/wiki/Antisense_therapy). I have targeted the dna N gene (Gene ID 887092) (http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=57116681 from 2052 to 3260) of Mycobacterium tuberculosis H37Rv strain which is a DNA Polymerase III and is a complex, multi-chain enzyme responsible for most of the replicative process in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
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[http://crdd.osdd.net/drugpedia/index.php/Category:Mtb_Immunotation Mtb Immunotation] : Immunological Annotation of Mtb Proteins
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A brief description of the method is as follows:
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[http://crdd.osdd.net/drugpedia/index.php/Category:BIAdb BIAdb] :  A Database for Benzylisoquinoline Alkaloids
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•The sequence of the dna N gene has been analyzed for GC rich region which is from 2152 to 2172 of coding region (Total length of dna N gene in the genome of Mycobacterium 2052 to 3260).
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[http://crdd.osdd.net/drugpedia/index.php/Category:HMRbase HMRbase] :  A database of hormones and their receptors
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•The sequence was aligned with both the human genome (host of Mycobacterium tuberculosis) and Mycobacterium genome itself using the BLAST tool.
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[http://crdd.osdd.net/drugpedia/index.php/Category:PolysacDB PolysacDB] : A database of polysaccharide antigens and their antibodies
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•It was found that there was no significant homology between the genome of human and the oligonucleotide we are going to use for Antisense against dna N gene. This shows that the oligo would act specifically against Mycobacterium.
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[[Bioinformatics Guide]] Bioinformatics Guide
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•It was also observed that the oligo has homology with other gene of Mycobacterium tuberculosis H37Rv strain.
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== News From Raghava's Group ==
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•Then an expression vector (eg:  pCS 105 vector modified by Duve Turner’s) has been designed that will produce the antisense against the transcribed portion of dna N gene.
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Ansari, H.R. and Raghava, G.P.S (2010) Identification of conformational B-cell Epitopes in an antigen from its primary sequence [http://www.immunome-research.com/content/6/1/6/abstract Immunome Research 2010, 6:6]
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•This vector has been transfected into the cell.
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==Experience certificates==
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While on one hand we bewail the "lack of manpower", it is an unpalatable fact that many educated youngsters do not have appropriate jobs. There is obviously a gap between what the employers require and the level of knowledge or expertise the youth have. Unemployed youths who need experience certificate are requested to contribute generously to Drugpedia. We will issue a certificate for those who contribute significantly to Drugpedia (at least 10 important articles). 
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•The vector would transcribe the antisense and this antisense result in DNA/RNA hybrid and RNase H degrade that hybrid resulting in no translation and killing of our target.
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==Virtual Jobs==
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We are working on concept of virtual job where employee can contribute from their home (for example women’s). We will prefer to hire those who have contributed maximum information to Drugpedia.
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References:
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==Assignments==
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Dye,C., Scheele,S., Dolin,P., Pathania,V., and Raviglione,R.C. (1999). Global burden of tuberculosis—estimated incidence, prevalence, and mortality by country. J. Am. Med. Assn. 282,677–686
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All faculty members are requested to encourage students to contribute to Drugpedia. You may give assignment to students for contributing articles to Drugpedia.
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==Credit==
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Drugpedia uses popular software MediaWiki which maintain history of articles added/edited by users. It means all your contribution will be recorded so that you may get full credit of your contribution.   
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==Contact Information==
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This site is maintained by [http://www.imtech.res.in/raghava/ Dr GPS Raghava's] group at Institute of Microbial Technology, Chandigarh, india. Contact side [http://crdd.osdd.net/cont.php administrator].
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==Indipedia: A wikipedia for India==
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If you  wish to contribute to a subject related to India then click on [http://crdd.osdd.net/indipedia/ Indipedia].

Current revision

Consult the User's Guide and FAQ for information on using the wiki software.

Contents

DrugPedia: A Wikipedia for Drug Discovery

  • Drugpedia is a wikipedia created for collecting and compiling information related to computer-aided drug design.
  • The aim of Drugpedia is to provide comprehensive information about drugs.
  • Drugpedia is developed under the umbrella of Open Source Drug Discovery (OSDD) project.
  • Dudpedia covers wide range of subjects around drugs like Bioinformatics, Cheminfiormatics, clinical informatics etc.

Virtual Summer Trainees

Students often find it difficult to get placements for training (short/long/summer training), which is mandatory requirement for getting a degree. The Drugpedia provide opportunity for students to take small projects related to information collection and compilation. We may issue a certificate for students who contribute significantly to Drugpedia (at least 10 important articles).

Important databases and Projects

Mtb_Station : M'ycobacterium tuberculosis Structural Annotation

Mtb Immunotation : Immunological Annotation of Mtb Proteins

BIAdb : A Database for Benzylisoquinoline Alkaloids

HMRbase : A database of hormones and their receptors

PolysacDB : A database of polysaccharide antigens and their antibodies

Bioinformatics Guide Bioinformatics Guide

News From Raghava's Group

Ansari, H.R. and Raghava, G.P.S (2010) Identification of conformational B-cell Epitopes in an antigen from its primary sequence Immunome Research 2010, 6:6

Experience certificates

While on one hand we bewail the "lack of manpower", it is an unpalatable fact that many educated youngsters do not have appropriate jobs. There is obviously a gap between what the employers require and the level of knowledge or expertise the youth have. Unemployed youths who need experience certificate are requested to contribute generously to Drugpedia. We will issue a certificate for those who contribute significantly to Drugpedia (at least 10 important articles).

Virtual Jobs

We are working on concept of virtual job where employee can contribute from their home (for example women’s). We will prefer to hire those who have contributed maximum information to Drugpedia.

Assignments

All faculty members are requested to encourage students to contribute to Drugpedia. You may give assignment to students for contributing articles to Drugpedia.

Credit

Drugpedia uses popular software MediaWiki which maintain history of articles added/edited by users. It means all your contribution will be recorded so that you may get full credit of your contribution.

Contact Information

This site is maintained by Dr GPS Raghava's group at Institute of Microbial Technology, Chandigarh, india. Contact side administrator.

Indipedia: A wikipedia for India

If you wish to contribute to a subject related to India then click on Indipedia.

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