Human serum albumin
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The italicized first 24 amino acids are signal and propeptide portions not observed in the transcribed, translated and transported protein but present in the gene. There are 609 amino acids in this sequence with only 585 amino acids in the final product observed in the blood. | The italicized first 24 amino acids are signal and propeptide portions not observed in the transcribed, translated and transported protein but present in the gene. There are 609 amino acids in this sequence with only 585 amino acids in the final product observed in the blood. | ||
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Current revision
Human serum albumin
It is the most abundant protein in human blood plasma. It is produced in the liver. Albumin comprises about half of the blood serum protein. It is soluble and monomeric.
Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin.
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[edit] Functions of Human serum albumin
The following functions are performed by Human serum albumin:
- Prevents photodegradation of folic acid
- Transports unconjugated bilirubin
- Transports fat soluble hormones
- Transports thyroid hormones
- Transports many drugs; serum albumin levels can affect the half-life of drugs
- Maintains oncotic pressure
- Competitively binds calcium ions (Ca2+)
- Buffers pH
[edit] Measurement
It is a component of the Liver Function Tests (LFTs) but may be ordered separately. Albumin can be measured in Serum (yellow-top tube), plain tube with no additives (red-top tube) or heparin plasma (green-top tube). The reference interval is 36 - 52 g/L. (note upper limit increased from 47 g/L on the 15th June 2007). One of the method used is Bromocresol green on a Roche Modular or Olympus AU2700 analyser.
[edit] Interactions
Human serum albumin has been shown to interact with FCGRT.
[edit] Sequence
The following is available amino acid sequence of Human serum albumin:
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV AASQAALGL
The italicized first 24 amino acids are signal and propeptide portions not observed in the transcribed, translated and transported protein but present in the gene. There are 609 amino acids in this sequence with only 585 amino acids in the final product observed in the blood.
