PolysacDB Lipopolysaccharide 2170

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Current revision (05:52, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Salmonella typhimurium

[edit] Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab MO4-3

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA, immunoblotting

[edit] Cross-reactivity

This Mab was also specific but cross-reacted with Salmonella paratyphi serogroup A

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab can be used as a serotyping reagent for the identification of serogroup B salmonellae in a routine diagnostic bacteriology laboratory

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database