PolysacDB Lipopolysaccharide 2030
From DrugPedia: A Wikipedia for Drug discovery
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[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Pseudomonas aeruginosa
[edit] Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Heat killed Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab P6-2A2
[edit] Antibody type and class
IgG2a
[edit] Assay System
ELISA, immunoblotting, opsonophagocytic assay and in vivo protection assay
[edit] Cross-reactivity
This Mab reacted with strains Fisher IT-1, 06a,6b, and 06a,6d and did not react with strain 06a, 6c
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab demonstrated opsonophagocytic killing of 06 subtype strains in the presence of human peripheral blood leukocytes and fresh human serum. This Mab also showed in vivo protection
