PolysacDB Capsular polysaccharide 1835

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:10, 8 April 2010 (edit) Raghavagps (Talk | contribs) m (1 revision) ← Previous diff

Current revision (05:51, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Escherichia coli K1 strain

[edit] Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

[edit] Proposed functions

It is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab HmenB4

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, flow cytometry and bactericidal assay

[edit] Cross-reactivity

This Mab cross-reacted with Neisseria meningitidis Group B capsular polysaccharide and EV36 which is an E. coli K-12 strain possessing the genes for K1 capsular polysaccharide production and expresses non-acetylated α (2-->8) polysaccharide just like Neisseria meningitidis group B capsular polysaccharide. This Mab also reacted on the surface of human neuroblastoma cell line, CHP-134

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab readily killed group B meningococci in the presence of rabbit complement

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database